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Herein, we highlight current knowledge on bacterial tropones and their derivatives such as tropolones, tropodithietic acid, and roseobacticides. Their unusual biosynthesis depends on a universal CoA\u2010bound precursor featuring a seven\u2010membered carbon ring as backbone, which is generated by a side reaction of the phenylacetic acid catabolic pathway. Enzymes encoded by separate gene clusters then further modify this key intermediate by oxidation, CoA\u2010release, or incorporation of sulfur among other reactions. Tropones play important roles in the terrestrial and marine environment where they act as antibiotics, algaecides, or quorum sensing signals, while their bacterial producers are often involved in symbiotic interactions with plants and marine invertebrates (e.\u2009g., algae, corals, sponges, or mollusks). Because of their potent bioactivities and of slowly developing bacterial resistance, tropones and their derivatives hold great promise for biomedical or biotechnological applications, for instance as antibiotics in (shell)fish aquaculture.<\/jats:p>","DOI":"10.1002\/cbic.201900786","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T07:37:35Z","timestamp":1585813055000},"page":"2384-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential"],"prefix":"10.1002","volume":"21","author":[{"given":"Ying","family":"Duan","sequence":"first","affiliation":[{"name":"Faculty of Biology University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Petzold","sequence":"additional","affiliation":[{"name":"Faculty of Biology University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raspudin","family":"Saleem\u2010Batcha","sequence":"additional","affiliation":[{"name":"Faculty of Biology University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-7248","authenticated-orcid":false,"given":"Robin","family":"Teufel","sequence":"additional","affiliation":[{"name":"Faculty of Biology University of Freiburg  79104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"\u00a0"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2017.06.008"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.12.58"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-44964-7_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3496"},{"key":"e_1_2_9_6_1","unstructured":"\u00a0"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2016.01.001"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12643"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201405694"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303733"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja807827k"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02339-07"},{"key":"e_1_2_9_13_1","unstructured":"\u00a0"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00074"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802066"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201701223"},{"key":"e_1_2_9_17_1","unstructured":"H. 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