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However, most of them display optimal performance under strongly acidic conditions (pH\u20053\u20134), and are thus not feasible for many medical uses, including burn infections with a wound pH close to neutral. Herein, we report a copper\u2010based nanozyme (CuCo<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub>) that exhibits intrinsic peroxidase\u2010like activity and can convert H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> into <jats:sup>.<\/jats:sup>OH at neutral pH. In particular, bimetallic CuCo<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub> nanoparticles (NPs) exhibited enhanced peroxidase\u2010like activity and antibacterial capacity, superior to that of the corresponding monometallic CuS and CoS NPs. The CuCo<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub> nanozymes possessed excellent ability to kill various bacteria, including methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA). Furthermore, this CuCo<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub> nanozymes could effectively disrupt MRSA biofilms in\u2005vitro and accelerate MRSA\u2010infected burn healing in\u2005vivo. This work provides a new peroxidase mimic to combat bacteria in neutral pH milieu and this CuCo<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub> nanozyme could be a promising antibacterial agent for the treatment of burn infections.<\/jats:p>","DOI":"10.1002\/cbic.202000066","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:05:47Z","timestamp":1588118747000},"page":"2620-2627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Bimetallic CuCo<sub>2<\/sub>S<sub>4<\/sub> Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-7808","authenticated-orcid":false,"given":"Dandan","family":"Li","sequence":"first","affiliation":[{"name":"Department Institute of Translational Medicine, Medical College Yangzhou University  Yangzhou 225001 Jiangsu P. R. 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