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These <jats:italic>o<\/jats:italic>\u2010quinones were condensed with a number of <jats:italic>o<\/jats:italic>\u2010phenylenediamines to form isoindoline\u2010phenazines in high yields. Subsequent oxidation gave phenazine\u2010di\u2010<jats:italic>N<\/jats:italic>\u2010oxide isoindoline nitroxides that were evaluated for noncovalent and site\u2010directed spin\u2010labeling of duplex DNA and RNA that contained abasic sites. Although only minor binding was observed for RNA, the unsubstituted phenazine\u2010<jats:italic>N,N<\/jats:italic>\u2010dioxide tetramethyl isoindoline nitroxide showed high binding affinity and selectivity towards abasic sites in duplex DNA that contained cytosine as the orphan base.<\/jats:p>","DOI":"10.1002\/cbic.202000128","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T15:46:05Z","timestamp":1588261565000},"page":"2635-2642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nitroxide\u2010Derived <i>N<\/i>\u2010Oxide Phenazines for Noncovalent Spin\u2010Labeling of DNA"],"prefix":"10.1002","volume":"21","author":[{"given":"Haraldur Y.","family":"Juliusson","sequence":"first","affiliation":[{"name":"Department of Chemistry Science Institute University of Iceland  Dunhaga 3 107 Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-1456","authenticated-orcid":false,"given":"Snorri Th.","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry Science Institute University of Iceland  Dunhaga 3 107 Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"408","volume":"15","author":"S\u00e9rie T.","year":"1845","journal-title":"Ann. 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