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[Cu<jats:sub>3<\/jats:sub>Cl<jats:sub>4<\/jats:sub>(naphtpy)<jats:sub>2<\/jats:sub>][CuCl<jats:sub>2<\/jats:sub>] (<jats:bold>1<\/jats:bold>), [Cu<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub>(naphtpy)<jats:sub>2<\/jats:sub>](ClO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub> (<jats:bold>2<\/jats:bold>), [CuCl<jats:sub>2<\/jats:sub>(naphtpy)]<jats:sub>2<\/jats:sub>(MeOH)<jats:sub>3<\/jats:sub>(H<jats:sub>2<\/jats:sub>O) (<jats:bold>3<\/jats:bold>), [CuCl<jats:sub>2<\/jats:sub>(Cltpy)] (<jats:bold>4<\/jats:bold>) and [Cu(Cltpy)<jats:sub>2<\/jats:sub>](ClO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub> (<jats:bold>5<\/jats:bold>); (where naphtpy stands for 4\u2019\u2010((naphthalen\u20102\u2010yl)methoxy)\u20102,2\u2032:6\u2032,2\u2032\u2032\u2010terpyridine and Cltpy for 4\u2032\u2010chloro\u20102,2\u2032:6\u2032,2\u2032\u2032\u2010terpyridine). Their ability to interact with DNA was investigated, and their cytotoxic behaviour was examined with three cells lines, namely human ovarian carcinoma cells (A2780), their derived cisplatin\u2010resistant line (A2780cis), and human cervix adenocarcinoma cells (HeLa). All compounds show good cytotoxic properties (especially after 72\u2005h of incubation). Remarkably, two compounds, <jats:bold>4<\/jats:bold> and <jats:bold>5<\/jats:bold>, are still almost inactive after 24\u2005h (particularly <jats:bold>4<\/jats:bold>), but are highly active after 72\u2005h, with IC<jats:sub>50<\/jats:sub> values in the low\u2010micromolar to sub\u2010micromolar range. Compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> induce necrosis, whereas late apoptosis is observed with <jats:bold>3<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>, <jats:bold>4<\/jats:bold> exhibiting a behaviour close to that of cisplatin.<\/jats:p>","DOI":"10.1002\/cbic.202000154","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T22:48:54Z","timestamp":1585090134000},"page":"2348-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Time\u2010Dependent Cytotoxic Properties of Terpyridine\u2010Based Copper Complexes"],"prefix":"10.1002","volume":"21","author":[{"given":"Jordi","family":"Grau","sequence":"first","affiliation":[{"name":"nanoBIC, Department of Inorganic and Organic Chemistry Inorganic Chemistry Section University of Barcelona  Mart\u00ed i Franqu\u00e8s 1\u201311 08028 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-6231","authenticated-orcid":false,"given":"Amparo","family":"Caubet","sequence":"additional","affiliation":[{"name":"nanoBIC, Department of Inorganic and Organic Chemistry Inorganic Chemistry Section University of Barcelona  Mart\u00ed i Franqu\u00e8s 1\u201311 08028 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-5843","authenticated-orcid":false,"given":"Olivier","family":"Roubeau","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia de Materiales de Arag\u00f3n CSIC and Universidad de Zaragoza  Plaza San Francisco s\/n 50009 Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Montpey\u00f3","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Bioqu\u00edmica i de Biologia Molecular Universitat Aut\u00f2noma de Barcelona, Bellaterra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5659-6008","authenticated-orcid":false,"given":"Julia","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i de Biomedicina and Departament de Bioqu\u00edmica i de Biologia Molecular Universitat Aut\u00f2noma de Barcelona, Bellaterra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-9525","authenticated-orcid":false,"given":"Patrick","family":"Gamez","sequence":"additional","affiliation":[{"name":"nanoBIC, Department of Inorganic and Organic Chemistry Inorganic Chemistry Section University of Barcelona  Mart\u00ed i Franqu\u00e8s 1\u201311 08028 Barcelona Spain"},{"name":"Catalan Institution for Research and Advanced Studies (ICREA)  Passeig Llu\u00eds Companys 23 08010 Barcelona Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB)  Universitat de Barcelona 08028 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00022a011"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583510000181"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.10.029"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b418164f"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc30952a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"M. 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