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Herein, we report that 2\u2010aminobenzothiazoles block histidine kinase\u2010dependent phenotypes in <jats:italic>Salmonella enterica<\/jats:italic> serotype Typhimurium. We found that 2\u2010aminobenzothiazoles inhibited growth under low Mg<jats:sup>2+<\/jats:sup>, a stressful condition that requires histidine kinase\u2010mediated responses, and decreased expression of the virulence genes <jats:italic>pagC<\/jats:italic> and <jats:italic>pagK<\/jats:italic>. Furthermore, we discovered that 2\u2010aminobenzothiazoles weaken <jats:italic>Salmonella<\/jats:italic>\u2019s resistance to polymyxin B and polymyxin E, which are last\u2010line antibiotics and models for host defense CAMPs. These findings raise the possibilities that 2\u2010aminobenzothiazoles can block HK\u2010mediated bacterial defenses and can be used in combination with polymyxins to treat infections caused by <jats:italic>Salmonella<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cbic.202000422","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:40:32Z","timestamp":1596555632000},"page":"3500-3503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["2\u2010Aminobenzothiazoles Inhibit Virulence Gene Expression and Block Polymyxin Resistance in <i>Salmonella enterica<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Michaela K.","family":"Thielen","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2013La Crosse  1725 State St La Crosse WI 54601 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody K.","family":"Vaneerd","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2013La Crosse  1725 State St La Crosse WI 54601 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manibarsha","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Minnesota  207 Pleasant St. SE Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-8893","authenticated-orcid":false,"given":"Erin E.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Minnesota  207 Pleasant St. SE Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-240X","authenticated-orcid":false,"given":"John F.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Wisconsin\u2013La Crosse  1725 State St La Crosse WI 54601 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"crossref","first-page":"0014","DOI":"10.1128\/microbiolspec.ARBA-0014-2017","volume":"6","author":"McDermott P. 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