{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:21:47Z","timestamp":1791598907827,"version":"4.3.4"},"reference-count":153,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM130183"],"award-info":[{"award-number":["GM130183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is an environmental toxin and a heritage of ancient microbial metabolism that has stimulated new interest following its discovery as a neuromodulator. While many physiological responses have been attributed to low H\n                    <jats:sub>2<\/jats:sub>\n                    S levels, higher levels inhibit complex IV in the electron transport chain. To prevent respiratory poisoning, a dedicated set of enzymes that make up the mitochondrial sulfide oxidation pathway exists to clear H\n                    <jats:sub>2<\/jats:sub>\n                    S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    reduction in the electron transport chain. The SQOR reaction prevents H\n                    <jats:sub>2<\/jats:sub>\n                    S accumulation and generates highly reactive persulfide species as products; these can be further oxidized or can modify cysteine residues in proteins by persulfidation. Here, we review the kinetic and structural characteristics of human SQOR, and how its unconventional redox cofactor configuration and substrate promiscuity lead to sulfide clearance and potentially expand the signaling potential of H\n                    <jats:sub>2<\/jats:sub>\n                    S. This dual role of SQOR makes it a promising target for H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010based therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202000661","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T13:11:18Z","timestamp":1603199478000},"page":"949-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Hydrogen Sulfide Oxidation by Sulfide Quinone Oxidoreductase"],"prefix":"10.1002","volume":"22","author":[{"given":"Aaron P.","family":"Landry","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry University of Michigan Medical School  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Ballou","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry University of Michigan Medical School  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-3275","authenticated-orcid":false,"given":"Ruma","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry University of Michigan Medical School  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.20.6.598"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1967.sp001909"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3678"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408448409029321"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2919"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4310"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009442"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000387"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306241110"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.09.027"},{"key":"e_1_2_9_12_1","first-page":"208","volume":"11","author":"Coletta C.","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0573-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024535"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","volume":"127","author":"Sun L.","year":"2014","journal-title":"Chin. Med. J."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002208"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025943"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108581"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5901"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.517"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020150124721"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.268re2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/es60065a008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1834"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000826"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10067"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.09.018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(80)90009-0"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi001088w"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.02.004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808026200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010868"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3781"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.466177"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012616"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90566.2008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3525"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1992.tb04882.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800413"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.174136"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5312"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902952106"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.5.G922"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr9002504"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0850623"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006838231432"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06482.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi300778t"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.602664"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.788547"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1907"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.407411"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.675694"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9020296"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.3000"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00821-2"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00188-O"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.4.654"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004140050071"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419-007-0033-7"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(04)78003-4"},{"key":"e_1_2_9_66_1","doi-asserted-by":"crossref","unstructured":"S.\u2005M. Miller Handbook of Flavoproteins Vol.\u20052: Complex Flavoproteins Dehydrogenases and Physical Methods 1st ed de Gruyter 2013 pp.\u2005165\u2013202.","DOI":"10.1515\/9783110298345.165"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(01)58006-7"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900887k"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904165106"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9003827"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.03.018"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.03.002"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.09.010"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msg174"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/018580-0"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22665"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2018.04.004"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939681"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050615"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)00002-7"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.682369"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7407com"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2012.04.007"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb19948.x"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1994.tb01372.x"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1996.tb01360.x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9605915"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3558"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06066"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321232111"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10494"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.672816"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00258"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197711102971902"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00391.x"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.09.018"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12521"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0006-7"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)63444-7"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97085-7"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33165-4"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33341-0"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.3621"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00100a016"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34723-9"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7712"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/1891007a0"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1030791"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.6.897"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01093"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(81)90519-8"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652039209374109"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60166-7"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77815-6"},{"key":"e_1_2_9_115_1","unstructured":"D. Benchoam J.\u2005A. Semelak E. Cuevasanta M. Mastrogiovanni J.\u2005S. Grassano G. Ferrer-Sueta A. Zeida M. Trujillo M.\u2005N. M\u00f6ller D.\u2005A. Estrin J. Biol. Chem.2020 DOI: 10.1074\/jbc-.RA120.014728."},{"key":"e_1_2_9_116_1","unstructured":"D.\u2005C. Brune Anoxygenic Photosynthetic Bacteria1995 Springer Dordrecht 847\u2013870."},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)60018-1"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1000135707181"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.1996.tb00233.x"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.60.1.33"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(75)90174-7"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443662"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52408-X"},{"key":"e_1_2_9_124_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1242\/jeb.149.1.133","volume":"149","author":"O\u2032Brien J.","year":"1990","journal-title":"J. Exp. Biol."},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.233.4763.563"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00258979"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00699228"},{"key":"e_1_2_9_128_1","first-page":"A88","volume":"37","author":"V\u00f6lkel S.","year":"1994","journal-title":"Physiologist"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.00231.x"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.04.004"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(76)90252-6"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04223.x"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400007200"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1460223"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.10.007"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2814477"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.016"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.017"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12232"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1086\/381653"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.697102"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710191104"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025476"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.778654"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.9.793"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03562.x"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R036012"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71290-8"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71291-X"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64668-X"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2180511"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1250879"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202000661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202000661","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202000661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:52:40Z","timestamp":1760277160000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202000661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":153,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3,16]]}},"alternative-id":["10.1002\/cbic.202000661"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202000661","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}