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Antibody therapy and vaccines are promising approaches to treat the disease; however, they have bottlenecks: they might have low efficacy or narrow breadth due to the continuous emergence of new strains of the virus or antibodies could cause antibody\u2010dependent enhancement (ADE) of infection. To address these bottlenecks, I propose the use of 24\u2010meric ferritin for the synthesis of mosaic nanocages to deliver a cocktail of antibodies or nanobodies alone or in combination with another therapeutic, like a nucleotide analogue, to mimic the viral entry process and deceive the virus, or to develop mosaic vaccines. I argue that available data showing the effectiveness of ferritin\u2010antibody conjugates in targeting specific cells and ferritin\u2010haemagglutinin nanocages in developing influenza vaccines strongly support my proposals.<\/jats:p>","DOI":"10.1002\/cbic.202000728","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T15:40:19Z","timestamp":1608651619000},"page":"1371-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ferritin as a Platform for Creating Antiviral Mosaic Nanocages: Prospects for Treating COVID\u201019"],"prefix":"10.1002","volume":"22","author":[{"given":"Kourosh","family":"Honarmand Ebrahimi","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Oxford  Mansfield Road Oxford OX1 3TA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30484-9"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2020.08.003"},{"key":"e_1_2_2_5_1","unstructured":"J.\u2005L. 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