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In the presence of 1\u2005mM catalyst, the observed pH\u2013rate profile featured a new pH\u2010independent region between pH\u20056 and 7, the catalyzed reaction being as much as eight times faster than the background reaction. At pH\u20057, the acceleration increased linearly from three\u2010 to 17\u2010fold upon increasing the catalyst concentration from 1 to 7\u2005mM. The linear dependence indicates a relatively low affinity of the catalyst for the substrate and, hence, the potential for considerable improvement on tethering to an appropriate targeting group, such as an oligonucleotide.<\/jats:p>","DOI":"10.1002\/cbic.202000799","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:40:16Z","timestamp":1610736016000},"page":"1761-1764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cleavage of an RNA Model Compound by an Arylmercury Complex"],"prefix":"10.1002","volume":"22","author":[{"given":"Lange Yakubu","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Turku  Vatselankatu 2 20014 Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Ora","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Turku  Vatselankatu 2 20014 Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-3116","authenticated-orcid":false,"given":"Tuomas","family":"L\u00f6nnberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Turku  Vatselankatu 2 20014 Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.201600141"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja061036f"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.11.55"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1008739"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111856"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00469"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.12.005"},{"key":"e_1_2_2_8_1","first-page":"158","author":"Ghidini A.","year":"2015","journal-title":"DNA Supramol. 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