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Therefore, proper examination of the parasite's biology is pivotal to deciphering unique molecular, biochemical and cell biological processes, which in turn ensure the identification of treatment strategies, such as potent drug targets and vaccine candidates. However, implementing molecular biology methods for genetic manipulation proves to be difficult for many parasite model organisms. The development of fast and straightforward applicable alternatives, for instance small\u2010molecule probes from the field of chemical biology, is essential. In this review, we will recapitulate the highlights of previous molecular and chemical biology approaches that have already created insight and understanding of the malaria parasite\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . We discuss current developments from the field of chemical biology and explore how their application could advance research into this parasite in the future. We anticipate that the described approaches will help to close knowledge gaps in the biology of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    and we hope that researchers will be inspired to use these methods to gain knowledge \u2013 with the aim of ending this devastating disease.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202000882","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T07:21:01Z","timestamp":1613028061000},"page":"2219-2236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chemical Biology Tools To Investigate Malaria Parasites"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-6595","authenticated-orcid":false,"given":"Johannes","family":"Broichhagen","sequence":"first","affiliation":[{"name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP)  Robert-Roessle-Strasse 10 13125 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kilian","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases Parasitology Heidelberg University Hospital  Im Neuenheimer Feld 324 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"crossref","unstructured":"A.\u2005Hassl Wien. 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