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CA IX enzyme is known to play a crucial role in cancer cell proliferation and metastases. The new class of potent and selective CA IX inhibitors combines the structural motif of a bulky inorganic cluster with an alkylsulfamido or alkylsulfonamido anchor group for Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ion in the enzyme active site. Detailed structure\u2010activity relationship (SAR) studies of a large series containing 50 compounds uncovered structural features of the cluster\u2010containing inhibitors that are important for efficient and selective inhibition of CA IX activity. Preclinical evaluation of selected compounds revealed low toxicity, favorable pharmacokinetics and ability to reduce tumor growth. Cluster\u2010containing inhibitors of CA IX can thus be considered as promising candidates for drug development and\/or for combination therapy in boron neutron capture therapy (BNCT).\n                  <\/jats:p>","DOI":"10.1002\/cbic.202100121","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:14:09Z","timestamp":1620051249000},"page":"2741-2761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-9682","authenticated-orcid":false,"given":"Michael","family":"Kugler","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences  Flemingovo n\u00e1m. 2 16610 Prague Czech Republic"},{"name":"Institute of Molecular Genetics of the Czech Academy of Sciences  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