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In 1999 \u2013 with the demonstration of DAP's potential as a\u2005phosphorylating agent of sugars in aqueous medium \u2013 began the exciting phase of research about DAP's role as a\u2005plausible prebiotic phosphorylating agent. More recently, in the last five years, there has been a steady increase in the publications that have documented the surprising versatility of DAP enabling the emergence of many classes of biomolecules of life, such as nucleic acids, peptides and protocells. Thus, though in its infancy, DAP seems to be uniquely positioned to play a central role in modelling abiotic\u2010 to prebiotic\u2010chemical evolution. In this context, there is a need for systematic investigations for: (a)\u2005establishing DAP's likely availability on the early Earth, and (b)\u2005developing DAP's potential as a tool for use in synthetic and bioorganic chemistry.<\/jats:p>","DOI":"10.1002\/cbic.202100274","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T16:09:48Z","timestamp":1626883788000},"page":"3001-3009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential?"],"prefix":"10.1002","volume":"22","author":[{"given":"Abdulakeem","family":"Osumah","sequence":"first","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  10550 North Torrey Pines Rd La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-610X","authenticated-orcid":false,"given":"Ramanarayanan","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  10550 North Torrey Pines Rd La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,8]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"123","volume":"16","author":"Stokes H. 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