{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:07:18Z","timestamp":1773983238885,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHM 857\u201320-1"],"award-info":[{"award-number":["SCHM 857\u201320-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the past decade, a variety of carbon monoxide releasing molecules (CORMs) have been developed and tested. Some CORMs spontaneously release CO once in solution, while others require a trigger mechanism to release the bound CO from its molecular complex. The modulation of biological systems by CORMs depends largely on the spatiotemporal release of CO, which likely differs among the different types of CORMs. In spontaneously releasing CORMs, CO is released extracellularly and crosses the cell membrane to interact with intracellular targets. Other CORMs can directly release CO intracellularly, which may be a more efficient method to modulate biological systems. In the present study, we compared the efficacy of extracellular and intracellular CO\u2010releasing CORMs that either release CO spontaneously or require an enzymatic trigger. The efficacy of such CORMs to modulate HO\u20101 and VCAM\u20101 expression in TNF\u2010\u03b1\u2010stimulated human umbilical vein endothelial cells (HUVEC) was evaluated.<\/jats:p>","DOI":"10.1002\/cbic.202100452","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T20:46:47Z","timestamp":1634244407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Head\u2010to\u2010Head Comparison of Selected Extra\u2010 and Intracellular CO\u2010Releasing Molecules on Their CO\u2010Releasing and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"23","author":[{"given":"Yingchun","family":"Li","sequence":"first","affiliation":[{"name":"Vth medical Department Medical Faculty Mannheim University of Heidelberg  Theodor-Kutzer-Ufer 1\u20133 68167 Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hemmersbach","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu K\u00f6ln  Greinstrasse 4 50939 K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Krause","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu K\u00f6ln  Greinstrasse 4 50939 K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Sitnikov","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu K\u00f6ln  Greinstrasse 4 50939 K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Schlundt n\u00e9e G\u00f6derz","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu K\u00f6ln  Greinstrasse 4 50939 K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego O.","family":"Pastene Maldonado","sequence":"additional","affiliation":[{"name":"Vth medical Department Medical Faculty Mannheim University of Heidelberg  Theodor-Kutzer-Ufer 1\u20133 68167 Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-1827","authenticated-orcid":false,"given":"Hans\u2010G\u00fcnther","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu K\u00f6ln  Greinstrasse 4 50939 K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benito","family":"Yard","sequence":"additional","affiliation":[{"name":"Vth medical Department Medical Faculty Mannheim University of Heidelberg  Theodor-Kutzer-Ufer 1\u20133 68167 Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1275CI"},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2008.02.002"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63646-2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808891"},{"key":"e_1_2_7_7_1","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh0202.104530"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705825"},{"key":"e_1_2_7_10_1","unstructured":"For reviews see:"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01153"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/b719075a"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/b819091g"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.5b00458"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol4021089"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10800"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006598"},{"key":"e_1_2_7_19_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201006598"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt30662j"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/om300359a"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/om301233h"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.06.014"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.06.002"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502445"},{"key":"e_1_2_7_25_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201502445"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700488"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201901206"},{"key":"e_1_2_7_28_1","unstructured":"\u00a0"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00137a001"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc8001997"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/b905725k"},{"key":"e_1_2_7_32_1","first-page":"7","author":"Grether U.","year":"2001","journal-title":"Chem. Eur. J."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00163a016"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/zaac.19322040115"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT02966F"},{"key":"e_1_2_7_36_1","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.06.008"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060915"},{"key":"e_1_2_7_39_1","unstructured":"As shown in our previous studies (refs. [6e] and [6\u2009f]) the by-products formed in the course of the CO release i.\u2009e. cyclohexenone and Fe3+ do not exhibit pronounced cellular effects at the low concentrations used."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.058"},{"key":"e_1_2_7_41_1","unstructured":"\u00a0"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00215.x"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12680"},{"key":"e_1_2_7_44_1","unstructured":"\u00a0"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.917751"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01869-7"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01309-w"},{"key":"e_1_2_7_48_1","unstructured":"\u00a0"},{"key":"e_1_2_7_49_2","first-page":"2735","volume":"16","author":"Shi J.","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706241"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01254"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202100452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202100452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202100452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:46:58Z","timestamp":1760258818000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202100452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,5]]}},"alternative-id":["10.1002\/cbic.202100452"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202100452","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,26]]},"assertion":[{"value":"2021-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202100452"}}