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The specific nano\u2010bio interface phenomenon of human islet amyloid peptide (hIAPP) and MoS<jats:sub>2<\/jats:sub> nanosheet was investigated by using theoretical and experimental methods. The MoS<jats:sub>2<\/jats:sub> nanosheet enables the attraction of hIAPP monomer, dimer, and oligomer on its surface through van der Waals forces. Especially, the means of interaction between two hIAPP peptides might be changed by MoS<jats:sub>2<\/jats:sub> nanosheet. In addition, it is interesting to find that the hIAPP oligomer can stably interact with the MoS<jats:sub>2<\/jats:sub> nanosheet in one unique \u201cstanding\u201d binding mode with an entire exposed \u03b2\u2010sheet surface. All the interaction modes on the surface of MoS<jats:sub>2<\/jats:sub> nanosheet can be the essence of amyloid protein corona that may provide the venue to facilitate the fibrillation of hIAPP proteins. Further, it was verified experimentally that MoS<jats:sub>2<\/jats:sub> nanosheets could accelerate the fibrillation of hIAPP at a certain concentration mainly based on the newly formed nano\u2010bio interface. In general, our results provide insight into the molecular interaction mechanism of the nano\u2010bio interface within the amyloid protein corona, and shed light on the pathway of amyloid protein aggregation that is related to the evolution of amyloid diseases.<\/jats:p>","DOI":"10.1002\/cbic.202100581","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T06:14:28Z","timestamp":1635401668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interfacial Interactions within Amyloid Protein Corona Based on 2D MoS<sub>2<\/sub> Nanosheets"],"prefix":"10.1002","volume":"23","author":[{"given":"Rongrong","family":"Wu","sequence":"first","affiliation":[{"name":"Institute for Advanced Materials Jiangsu University  Xuefu Road 301 Zhenjiang 212000 P. R. 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