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Hybrid scaffolds <jats:bold>6<\/jats:bold>\u2013<jats:bold>8<\/jats:bold> were synthesized at 77\u201395\u2009% yields by regioselective copper\u2010catalysed azide\u2010alkyne cycloaddition (CuAAC) reaction of unpublished 6\u2010azido\u20104\u2010(trifluoromethyl)quinolines (<jats:bold>2<\/jats:bold>) with selected terminal alkynes (<jats:bold>3<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>). Azido intermediates <jats:bold>2<\/jats:bold> were obtained from the reaction of 6\u2010amino\u20104\u2010(trifluoromethyl)quinolines (<jats:bold>1<\/jats:bold>) and sodium azide at good yields (78\u201387\u2009%). Compounds <jats:bold>6<\/jats:bold>\u2013<jats:bold>8<\/jats:bold> were structurally fully characterized by <jats:sup>1<\/jats:sup>H\u2212, <jats:sup>13<\/jats:sup>C\u2212 and <jats:sup>19<\/jats:sup>F\u2212 and <jats:sup>1<\/jats:sup>H\u2212<jats:sup>13<\/jats:sup>C 2D\u2010NMR (HSQC, HMBC) spectroscopy, X\u2010ray diffraction (SC\u2010XRD) and HRMS analysis. Moreover, the photophysical properties, DNA\u2010 and HSA\u2010binding experiments (bio\u2010interactions), and molecular docking studies for compounds <jats:bold>6<\/jats:bold>\u2013<jats:bold>8<\/jats:bold> were performed. These are discussed and compared with similar compounds from recent research.<\/jats:p>","DOI":"10.1002\/cbic.202100649","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T09:24:52Z","timestamp":1638955492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hybridized 4\u2010Trifluoromethyl\u2010(1,2,3\u2010triazol\u20101\u2010yl)quinoline System: Synthesis, Photophysics, Selective DNA\/HSA Bio\u2010interactions and Molecular Docking"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-6888","authenticated-orcid":false,"given":"Yuri G.","family":"Kappenberg","sequence":"first","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Departamento de Qu\u00edmica Universidade Federal de Santa Maria  97105-900 \u2013 Santa Maria, RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-9456","authenticated-orcid":false,"given":"Felipe S.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Departamento de Qu\u00edmica Universidade Federal de Santa Maria  97105-900 \u2013 Santa Maria, RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilo","family":"Zanatta","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Departamento de Qu\u00edmica Universidade Federal de Santa Maria  97105-900 \u2013 Santa Maria, RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos A. P.","family":"Martins","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Departamento de Qu\u00edmica Universidade Federal de Santa Maria  97105-900 \u2013 Santa Maria, RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo A.","family":"Nogara","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria  97105-900 Santa Maria, RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o B. 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