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In recent years, ferroptosis inhibition has emerged as a novel strategy to target different pathologies. Here, we report the synthesis of two purine derivatives, <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>, for iron chelation strategy and evaluate their potency to inhibit erastin\u2010induced ferroptosis. Both compounds showed efficient iron chelation in solution as well as in cellular environment. The crystal structure of the purine derivatives with iron demonstrated a 2\u2009:\u20091 (ligand to metal center) stoichiometry for iron and purine derivative complexation. The synthesized compounds also decrease the reactive oxygen species concentration in cell cultures. Compound <jats:bold>2<\/jats:bold> showed better potency towards the prevention of ferroptotic cell death as compared to commercially available iron chelator in the erastin\u2010induced ferroptosis cell culture model. Such purine analogues are potential functional scaffolds for the development of target molecules for ferroptosis inhibition.<\/jats:p>","DOI":"10.1002\/cbic.202100654","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:56:40Z","timestamp":1645433800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhibiting Erastin\u2010Induced Ferroptotic Cell Death by Purine\u2010Based Chelators"],"prefix":"10.1002","volume":"23","author":[{"given":"Saurabh","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Chemistry Mehta Family Center for Engineering in Medicine Indian Institute of Technology Kanpur  Uttar Pradesh 208016 India"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur  Uttar Pradesh 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva","family":"Panjla","sequence":"additional","affiliation":[{"name":"Department of Chemistry Mehta Family Center for Engineering in Medicine Indian Institute of Technology Kanpur  Uttar Pradesh 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-660X","authenticated-orcid":false,"given":"Suresh","family":"Valiyaveettil","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur  Uttar Pradesh 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Mehta Family Center for Engineering in Medicine Indian Institute of Technology Kanpur  Uttar Pradesh 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","first-page":"51","volume":"37","author":"Wallace D. 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