{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:10:53Z","timestamp":1760274653983,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The new variant of concern of SARS\u2010CoV\u20102, namely Omicron, has triggered global fear recently. To date, our knowledge of Omicron, particularly of how S glycoprotein mutations affect the infectivity of the virus and the severity of the infection, is far from complete. This hinders our ability to treat the disease and to predict the future state of SARS\u2010CoV\u20102 threats to well\u2010being and economic stability. Despite this, efforts have been made to unveil the routes of transmission and the efficiency of existing vaccines in tackling Omicron. This article reviews the latest understanding of Omicron and the current status of the use of vaccines and drugs for infection control. It is hoped that this article can offer insights into the development of more effective measures to tackle the pandemic.<\/jats:p>","DOI":"10.1002\/cbic.202200126","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:57:33Z","timestamp":1648799853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Omicron: Understanding the Latest Variant of SARS\u2010CoV\u20102\u2009and Strategies for Tackling the Infection"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-9547","authenticated-orcid":false,"given":"Sreekanth Reddy","family":"Obireddy","sequence":"first","affiliation":[{"name":"Department of Urology Zhejiang Provincial People's Hospital Hangzhou Medical College  Zhejiang 310012 P. R. China"},{"name":"Department of Chemistry Sri Krishnadevaraya University  Anantapur 515003 India"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine The Chinese University of Hong Kong (Shenzhen)  Shenzhen 518172 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujwala","family":"Guntakanti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Krishnadevaraya University  Anantapur 515003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Kowthalam","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Krishnadevaraya University  Anantapur 515003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha","family":"Marata Chinna Subbarao","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sri Krishnadevaraya University  Anantapur 515003 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing\u2010Fu","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Urology Zhejiang Provincial People's Hospital Hangzhou Medical College  Zhejiang 310012 P. R. China"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine The Chinese University of Hong Kong (Shenzhen)  Shenzhen 518172 P. R. China"},{"name":"Department of Applied Biology and Chemical Technology Hong Kong Polytechnic University  Hong Kong Special Administrative Region P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"World Health Organization \u201cUpdate on Omicron\u201d can be found underhttps:\/\/www.who.int\/news\/item\/28-11-2021-update-on-omicron 2021."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105367"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27561"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-00471-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27560"},{"key":"e_1_2_8_7_1","unstructured":"World Health Organization \u201cTracking SARS-CoV-2 variants\u201d can be found underhttps:\/\/www.who.int\/en\/activities\/tracking-SARS-CoV-2-variants 2021."},{"key":"e_1_2_8_8_1","unstructured":"Centers for Disease Control and Prevention \u201cSARS-CoV-2 Variant Classifications and Definitions\u201d can be found underhttps:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/variants\/variant-info.html#anchor\u20021632158885160 2021."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27633"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27585"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106261"},{"key":"e_1_2_8_12_1","unstructured":"World Health Organization \u201cClassification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern\u201d can be found underhttps:\/\/www.who.int\/news\/item\/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern 2021."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106261"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00573-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.11.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2895-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00502-w"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2022.830202"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.04.21267284"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.059"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04479-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.045"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-00210-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd3255"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.046"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.032"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2021.12.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.01.007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04005-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102779"},{"key":"e_1_2_8_33_1","unstructured":"U.S. Food and Drug Administration \u201cU.S. Food and Drug Administration Center for Drug Evaluation and Research FDA Briefing Document \u2013 Antimicrobial Drugs Advisory Committee Meeting November 30 2021\u201d can be found underhttps:\/\/www.fda.gov\/media\/154418\/download 2021."},{"key":"e_1_2_8_34_1","unstructured":"M. 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