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Formation of amyloid \u03b2 (A\u03b2) fibrils that deposit as amyloid plaques in Alzheimer's disease (AD) brains is an earliest pathological hallmark. The polysulfated heparan sulfate (HS)\/heparin (HP) is one of the non\u2010protein components of A\u03b2 deposits that not only modulates A\u03b2 aggregation, but also acts as a receptor for A\u03b2 fibrils to mediate their cytotoxicity. Interfering with the interaction between HS\/HP and A\u03b2 could be a therapeutic strategy to arrest amyloidosis. Here we have synthesized the 6\u2010<jats:italic>O<\/jats:italic>\u2010phosphorylated HS\/HP oligosaccharides and reported their competitive effects on the inhibition of HP\u2010mediated A\u03b2 fibril formation <jats:italic>in\u2005vitro<\/jats:italic> using a thioflavin T fluorescence assay and a tapping mode atomic force microscopy.<\/jats:p>","DOI":"10.1002\/cbic.202200191","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T01:50:12Z","timestamp":1652925012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Design and Synthesis of 6\u2010<i>O<\/i>\u2010Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid \u03b2 Aggregation"],"prefix":"10.1002","volume":"23","author":[{"given":"Kenji","family":"Uchimura","sequence":"first","affiliation":[{"name":"Univ. 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