{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:47Z","timestamp":1791302567601,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Formaldehyde is a toxic metabolite that is formed in large quantities during bacterial utilization of the methoxy sugar 6\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010methyl\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose, an abundant monosaccharide in the red algal polysaccharide porphyran. Marine bacteria capable of metabolizing porphyran must therefore possess suitable detoxification systems for formaldehyde. We demonstrate here that detoxification of formaldehyde in the marine Flavobacterium\n                    <jats:italic>Zobellia galactanivorans<\/jats:italic>\n                    proceeds via the ribulose monophosphate pathway. Simultaneously, we show that the genes encoding the key enzymes of this pathway are important for maintaining high formaldehyde resistance. Additionally, these genes are upregulated in the presence of porphyran, allowing us to connect porphyran degradation to the detoxification of formed formaldehyde.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202200269","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T13:18:36Z","timestamp":1652447916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Connecting Algal Polysaccharide Degradation to Formaldehyde Detoxification"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-7706","authenticated-orcid":false,"given":"Stefan","family":"Brott","sequence":"first","affiliation":[{"name":"Department of Biotechnology &amp; Enzyme Catalysis Institute of Biochemistry University of Greifswald  Greifswald 17487 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-0774","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Thomas","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Biology of Marine Models (LBI2\u2005M) Station Biologique de Roscoff (SBR) Sorbonne Universit\u00e9, CNRS  29688 Roscoff Bretagne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-588X","authenticated-orcid":false,"given":"Maike","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department of Biotechnology &amp; 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