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Utilization of ligands containing NNO\u2010coordination site and binding zinc metal ion allowed mono\u2010 and tetra\u2010nuclear complexes to be obtained with corner and grid structural type, respectively, thus affecting the overall charge of the compounds (from +1 to +8). We were able to examine for the first time the multivalency effect of metallosupramolecular species on their inhibitory abilities towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 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