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The gallium(III) complex <jats:bold>1<\/jats:bold> displays micromolar potency towards bulk osteosarcoma cells and osteosarcoma stem cells (OSCs). Notably, the gallium(III) complex <jats:bold>1<\/jats:bold> exhibits significantly higher toxicity towards OSCs grown in monolayer and three\u2010dimensional cultures than cisplatin, a frontline anti\u2010osteosarcoma drug. Nuclei isolation and immunoblotting studies show that the gallium(III) complex <jats:bold>1<\/jats:bold> enters osteosarcoma cell nuclei and induces DNA damage. Flow cytometry and cytotoxicity studies (in the presence of prostaglandin E2) indicate that the gallium(III) complex <jats:bold>1<\/jats:bold> downregulates cyclooxygenase\u20102 (COX\u20102) expression and kills osteosarcoma cells in a COX\u20102\u2010dependent manner. Further, the mode of osteosarcoma cell death evoked by the gallium(III) complex <jats:bold>1<\/jats:bold> is characterised as caspase\u2010dependent apoptosis.<\/jats:p>","DOI":"10.1002\/cbic.202200532","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T06:53:05Z","timestamp":1666680785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Osteosarcoma Stem Cell Activity of a Gallium(III)\u2010Phenanthroline Complex Appended to Salicylate"],"prefix":"10.1002","volume":"23","author":[{"given":"Ruby A.","family":"Vincent","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Leicester  LE1\u20097RH Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginevra","family":"Passeri","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Leicester  LE1\u20097RH Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Northcote\u2010Smith","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Leicester  LE1\u20097RH Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldip","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Leicester  LE1\u20097RH Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-6384","authenticated-orcid":false,"given":"Kogularamanan","family":"Suntharalingam","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Leicester  LE1\u20097RH Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","unstructured":"S. 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