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In this work, we have used a unique approach to design a chimeric peptide, prepared by fusion of the best features of two peptide inhibitors, that has displayed parasite growth inhibition ex vivo with nanomolar IC\n                    <jats:sub>50<\/jats:sub>\n                    , which is 100 times better than any of its parent peptides. Furthermore, to gain structural insights, we computationally modelled the hybrid peptide on its receptor.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202200533","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T13:41:03Z","timestamp":1669815663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Chimeric Peptide Inhibits Red Blood Cell Invasion by\n                    <i>Plasmodium falciparum<\/i>\n                    with Hundredfold Increased Efficacy**"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-2423","authenticated-orcid":false,"given":"Jamsad","family":"Mannuthodikayil","sequence":"first","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Sinha","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Singh","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Biswas","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad","family":"Ali","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purna Chandra","family":"Mashurabad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Life Sciences University of Hyderabad  Gachibowli Hyderabad 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahida","family":"Tabassum","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Life Sciences University of Hyderabad  Gachibowli Hyderabad 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Vydyam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Life Sciences University of Hyderabad  Gachibowli Hyderabad 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal Kanti","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Life Sciences University of Hyderabad  Gachibowli Hyderabad 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-1378","authenticated-orcid":false,"given":"Kalyaneswar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Tata Institute of Fundamental Research Hyderabad  36\/p Gopanpally Hyderabad Telangana 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"World Malaria Report 2020 WHO 2020."},{"key":"e_1_2_8_2_1","unstructured":"\u00a0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002755"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3261"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.07.001"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207985200"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034376b"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.10.6981-6989.2005"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808762200"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201100135"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500020m"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b03440"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct300400x"},{"key":"e_1_2_8_17_1","unstructured":"\u00a0"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(99)80023-2"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340170408"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(00)00061-0"},{"key":"e_1_2_8_21_2","unstructured":"M. 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