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The compounds were efficiently synthesized in nine or ten steps from\n                    <jats:sc>d<\/jats:sc>\n                    \u2010 or\n                    <jats:sc>l<\/jats:sc>\n                    \u2010arabinose, and the structures were confirmed by X\u2010ray crystallographic analysis of key intermediates. All compounds were inactive against IDUA, although\n                    <jats:sc>l<\/jats:sc>\n                    \u2010IdoA\u2010configured\n                    <jats:bold>8<\/jats:bold>\n                    moderately inhibited \u03b2\u2010glucuronidase (\u03b2\u2010GLU). The\n                    <jats:sc>d<\/jats:sc>\n                    \u2010GlcA\u2010configured\n                    <jats:bold>9<\/jats:bold>\n                    was a potent inhibitor of \u03b2\u2010GLU and a moderate inhibitor of the endo\u2010\u03b2\u2010glucuronidase heparanase. Co\u2010crystallization of\n                    <jats:bold>9<\/jats:bold>\n                    with heparanase revealed that the endocyclic nitrogen of\n                    <jats:bold>9<\/jats:bold>\n                    forms close interactions with both the catalytic acid and catalytic nucleophile.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202200619","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:30:50Z","timestamp":1669883450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis of Uronic Acid 1\u2010Azasugars as Putative Inhibitors of \u03b1\u2010Iduronidase, \u03b2\u2010Glucuronidase and Heparanase**"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7540-4419","authenticated-orcid":false,"given":"Gareth G.","family":"Doherty","sequence":"first","affiliation":[{"name":"School of Chemistry &amp; Molecular Biosciences The University of Queensland, Brisbane  Queensland 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-0743","authenticated-orcid":false,"given":"Geraldine Jia Ming","family":"Ler","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; 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