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However, the poor solubility and low bioavailability limit its clinical application. Here, we report an effective strategy to fabricate Cannabidiol\u2010loaded poly(lactic\u2010co\u2010glycolic acid) copolymer (CBD\u2010PLGA) nanoparticles (NPs), with a spherical morphology and an average diameter of 238\u2005nm. CBD was sustained release from CBD\u2010PLGA\u2010NPs, which improved the bioavailability of CBD. The CBD\u2010PLGA\u2010NPs effectively protect the damage of LPS to cell viability. We observed that CBD\u2010PLGA\u2010NPs significantly suppressed LPS\u2010induced primary rat chondrocyte expression of inflammatory cytokines, including interleukin 1\u03b2 (IL\u20101\u03b2), interleukin 6 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and matrix metalloproteinase 13 (MMP\u201013). Remarkably, CBD\u2010PLGA\u2010NPs also showed better therapeutic effects of inhibiting the degradation of the extracellular matrix of chondrocytes than equivalent CBD solution. In general, the fabrication CBD\u2010PLGA\u2010NPs showed good protection of primary chondrocytes in\u2005vitro and is a promising system for osteoarthritis treatment.<\/jats:p>","DOI":"10.1002\/cbic.202200698","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T01:03:42Z","timestamp":1676509422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cannabidiol\u2010Loaded Poly Lactic\u2010Co\u2010Glycolic Acid Nanoparticles with Improved Bioavailability as a Potential for Osteoarthritis Therapeutic"],"prefix":"10.1002","volume":"24","author":[{"given":"Zhiqiang","family":"Jin","sequence":"first","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning 530021 China"},{"name":"Department of Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of 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