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Mitochondrial diseases resulting from uncontrolled\/excess ROS generation are an emerging public health concern and there is current interest in specific mitochondriotropic probes to get information on in\u2010situ ROS production. As such, nitrones vectorized by the triphenylphosphonium (TPP) cation have recently drawn attention despite reported cytotoxicity. Herein, we describe the synthesis of 13 low\u2010toxic derivatives of <jats:italic>N<\/jats:italic>\u2010benzylidene\u20101\u2010diethoxyphosphoryl\u20101\u2010methylethylamine <jats:italic>N<\/jats:italic>\u2010oxide (PPN) alkyl chain\u2010grafted to a pyridinium, triethylammonium or berberinium lipophilic cation. These nitrones showed in\u2010vitro superoxide quenching activity and EPR\/spin\u2010trapping efficiency towards biologically relevant free radicals, including superoxide and hydroxyl radicals. Their mitochondrial penetration was confirmed by <jats:sup>31<\/jats:sup>P NMR spectroscopy, and their anti\u2010apoptotic properties were assessed in Schwann cells treated with hydrogen peroxide. Two pyridinium\u2010substituted PPNs were identified as potentially better alternatives to TPP nitrones conjugates for studying mitochondrial oxidative damage.<\/jats:p>","DOI":"10.1002\/cbic.202200749","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T05:34:30Z","timestamp":1676266470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New Biocompatible \u03b2\u2010Phosphorylated Linear Nitrones Targeting Mitochondria: Protective Effect in Apoptotic Cells"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-7591","authenticated-orcid":false,"given":"Marcel","family":"Culcasi","sequence":"first","affiliation":[{"name":"Aix Marseille Univ CNRS ICR SMBSO  Avenue Escadrille Normandie Niemen 13397 Marseille Cedex 20 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