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A\u03b242 aggregation kinetics, characterized by the quantification of A\u03b242 monomer consumption, were tracked by real\u2010time solution NMR spectroscopy (RT\u2010NMR) allowing the impact that low\u2010molecular\u2010weight (LMW) inhibitors and modulators exert on the aggregation process to be analysed. Distinct differences in the A\u03b242 kinetic profiles were apparent and were further investigated kinetically and structurally by using thioflavin\u2005T (ThT) and transmission electron microscopy (TEM), respectively. LMW inhibitors were shown to have a differential impact on early\u2010state aggregation. Insight provided here could direct future therapeutic design based on kinetic profiling of the process of fibril formation.<\/jats:p>","DOI":"10.1002\/cbic.202200760","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T16:04:37Z","timestamp":1674057877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Modulation of A\u03b242 Aggregation Kinetics and Pathway by Low\u2010Molecular\u2010Weight Inhibitors"],"prefix":"10.1002","volume":"24","author":[{"given":"Marie\u2010Theres","family":"Hutchison","sequence":"first","affiliation":[{"name":"Institute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ) Goethe University Frankfurt  Max-von-Laue-Str. 7 60438 Frankfurt\/Main 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