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Due to its exquisite selectivity towards pathogenic parasites, cladosporin has become a very promising lead compound for developing antiparasitic drugs to treat drug\u2010resistant malaria and cryptosporidiosis infections. Here we review the recent research progress of cladosporin covering aspects of the chemical synthesis, biosynthesis, bioactivity, cellular target and structure\u2013activity relationship.<\/jats:p>","DOI":"10.1002\/cbic.202300154","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T14:53:59Z","timestamp":1683730439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cladosporin, A Highly Potent Antimalaria Drug?"],"prefix":"10.1002","volume":"24","author":[{"given":"Anwei","family":"Hou","sequence":"first","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  West 7th Avenue No. 32 300308 Tianjin China"},{"name":"Institute of Microbiology Jiangxi Academy of Sciences  Changdong Road No. 7777 330096 Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  West 7th Avenue No. 32 300308 Tianjin China"},{"name":"Haihe Laboratory of Synthetic Biology  West 15th Avenue No. 21 300308 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Deng","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  West 7th Avenue No. 32 300308 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  West 7th Avenue No. 32 300308 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-0631","authenticated-orcid":false,"given":"Jeroen S.","family":"Dickschat","sequence":"additional","affiliation":[{"name":"Kekul\u00e9-Institute for Organic Chemistry and Biochemistry University of Bonn  Gerhard-Domagk-Stra\u00dfe 1 53121 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.24.747"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9040613"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/P19720002400"},{"key":"e_1_2_10_4_1","first-page":"4061","volume":"8","author":"Alwatban M. 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