{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:00:21Z","timestamp":1778482821511,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104797\/Z\/14\/Z"],"award-info":[{"award-number":["104797\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT220100152"],"award-info":[{"award-number":["FT220100152"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2023,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infections associated with antimicrobial resistance (AMR) are poised to become the leading cause of death in the next few decades, a scenario that can be ascribed to two phenomena: antibiotic over\u2010prescription and a lack of antibiotic drug development. The crowd\u2010sourced initiative Community for Open Antimicrobial Drug Discovery (CO\u2010ADD) has been testing research compounds contributed by researchers around the world to find new antimicrobials to combat AMR, and during this campaign has found that metallodrugs might be a promising, yet untapped source. To this end, we submitted 18 Pd\n                    <jats:sup>II<\/jats:sup>\n                    \u2212 and Ru\n                    <jats:sup>II<\/jats:sup>\n                    \u2212pyridyl\u22121,2,3\u2010triazolyl complexes that were developed as catalysts to assess their antimicrobial properties. It was found that the Pd complexes, especially\n                    <jats:bold>Pd1<\/jats:bold>\n                    , possessed potent antifungal activity with MICs between 0.06 and 0.125\u2005\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    . The in\u2010vitro studies were extended to in\u2010vivo studies in\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    larvae, where it was established that the compounds were nontoxic. Here, we effectively demonstrate the potential of Pd\n                    <jats:sup>II<\/jats:sup>\n                    \u2212pyta complexes as antifungal agents.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202300247","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T01:50:29Z","timestamp":1692409829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Antimicrobial Properties of Pd\n                    <sup>II<\/sup>\n                    \u2212 and Ru\n                    <sup>II<\/sup>\n                    \u2212pyta Complexes**"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-7400","authenticated-orcid":false,"given":"Annick","family":"van Niekerk","sequence":"first","affiliation":[{"name":"Department of Chemistry and Polymer Science University of Stellenbosch  Stellenbosch, Private bag X1, Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-5592","authenticated-orcid":false,"given":"M. Cassiem","family":"Joseph","sequence":"additional","affiliation":[{"name":"Molecular Science Institute, School of Chemistry University of the Witwatersrand  Johannesburg, PO Wits 2050 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hue","family":"Dinh","sequence":"additional","affiliation":[{"name":"School of Natural Sciences ARC Centre of Excellence in Synthetic Biology Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-8557","authenticated-orcid":false,"given":"Andrew J.","family":"Swarts","sequence":"additional","affiliation":[{"name":"Molecular Science Institute, School of Chemistry University of the Witwatersrand  Johannesburg, PO Wits 2050 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-0412","authenticated-orcid":false,"given":"Selwyn F.","family":"Mapolie","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Polymer Science University of Stellenbosch  Stellenbosch, Private bag X1, Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Zuegg","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-6572","authenticated-orcid":false,"given":"Amy K.","family":"Cain","sequence":"additional","affiliation":[{"name":"School of Natural Sciences ARC Centre of Excellence in Synthetic Biology Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-0484","authenticated-orcid":false,"given":"Alysha G.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-2292","authenticated-orcid":false,"given":"Mark A. T.","family":"Blaskovich","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-2491","authenticated-orcid":false,"given":"Angelo","family":"Frei","sequence":"additional","affiliation":[{"name":"Dept. of Chemistry, Biochemistry &amp; Pharmaceutical Sciences University of Bern  Freiestrasse 3 3012 Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10060745"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.46"},{"key":"e_1_2_8_4_1","first-page":"1","volume":"3099","author":"Rajasingham R.","year":"2022","journal-title":"Lancet Infect. 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