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Such complexes have been extensively investigated for their anticancer activity, with many displaying activities comparable or superior to available clinical chemotherapeutic drugs. Here, we evaluated a series of quinoline\u2010containing binuclear complexes and metallarectangles for their <jats:italic>in\u2005vitro<\/jats:italic> anticancer activity in the hormone receptor positive MCF\u20107 and triple negative MDA\u2010MB\u2010231 breast cancer cell lines. The preliminary cytotoxic screen, in the MCF\u20107\u2005cell line, revealed that the ligand (7\u2010chloro\u20104\u2010(pyridin\u20104\u2010yl)quinoline, <jats:bold>L<\/jats:bold>) and metallarectangle [{Ir(<jats:italic>\u03bc<\/jats:italic>\u2010Cl)(Cp*)}<jats:sub>4<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:bold>L<\/jats:bold>)<jats:sub>2<\/jats:sub>](OTf)<jats:sub>4<\/jats:sub> display superior activity to cisplatin, while [{Ru(<jats:italic>p<\/jats:italic>\u2010cymene)}<jats:sub>4<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010<jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010C<jats:sub>2<\/jats:sub>O<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:bold>L<\/jats:bold>)<jats:sub>2<\/jats:sub>](OTf)<jats:sub>4<\/jats:sub> was more potent than cisplatin in the triple\u2010negative MDA\u2010MD\u2010231\u2005cell line. Upon evaluation in a multidose screen, ligand <jats:bold>L<\/jats:bold> and metallarectangle [{Ir(<jats:italic>\u03bc<\/jats:italic>\u2010Cl)(Cp*)}<jats:sub>4<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:bold>L<\/jats:bold>)<jats:sub>2<\/jats:sub>](OTf)<jats:sub>4<\/jats:sub> displayed antiproliferative activity almost two\u2010fold greater than cisplatin in the MCF\u20107\u2005cell line, while [{Ru(<jats:italic>p<\/jats:italic>\u2010cymene)}<jats:sub>4<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010<jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010C<jats:sub>2<\/jats:sub>O<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>(<jats:italic>\u03bc<\/jats:italic>\u2010<jats:bold>L<\/jats:bold>)<jats:sub>2<\/jats:sub>](OTf)<jats:sub>4<\/jats:sub> was over two\u2010times more active than cisplatin in the MDA\u2010MB\u2010231\u2005cell line. Additionally, using the non\u2010tumorigenic MCF\u201012\u2005A breast epithelial cell line, the compounds demonstrate increased selectivity toward breast cancer cells over non\u2010tumorigenic cells. Furthermore, investigations into the interactions of ligand <jats:bold>L<\/jats:bold> and selected complexes with calf thymus DNA (CT\u2010DNA) and bovine serum albumin (BSA) indicate favourable binding.<\/jats:p>","DOI":"10.1002\/cbic.202300271","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T05:35:05Z","timestamp":1684215305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quinolyl\u2010Based PGM Metallarectangles: Antiproliferative Activity, DNA and BSA Protein Interactions, and a Molecular Docking Perspective"],"prefix":"10.1002","volume":"24","author":[{"given":"Taryn M.","family":"Golding","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Cape Town  Rondebosch 7701 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinner O.","family":"Omondi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cape Town  Rondebosch 7701 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supratim","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Human Biology University of Cape Town  Observatory 7925 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparna","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Human Biology University of Cape Town  Observatory 7925 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Human Biology University of Cape Town  Observatory 7925 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-5481","authenticated-orcid":false,"given":"Gregory S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cape Town  Rondebosch 7701 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer Accessed 12\/08\/2021."},{"key":"e_1_2_8_2_1","unstructured":"\u00a0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1595\/003214001X4526269"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","first-page":"1310","volume":"33","author":"DeConti R. 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