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Its macrophage infectivity potentiator (Mip), a member of a highly conserved family of FK506\u2010binding proteins (FKBPs), plays a major role in the proliferation of the gram\u2010negative bacterium in host organisms. In this work, we test our library of &gt;1000 FKBP\u2010focused ligands for inhibition of\n                    <jats:italic>Lp<\/jats:italic>\n                    Mip. The [4.3.1]\u2010bicyclic sulfonamide turned out as a highly preferred scaffold and provided the most potent\n                    <jats:italic>Lp<\/jats:italic>\n                    Mip inhibitors known so far. Selected compounds were non\u2010toxic to human cells, displayed antibacterial activity and block bacterial proliferation in cellular infection\u2010assays as well as infectivity in human lung tissue explants. The results confirm [4.3.1]\u2010bicyclic sulfonamides as anti\u2010legionellal agents, although their anti\u2010infective properties cannot be explained by inhibition of\n                    <jats:italic>Lp<\/jats:italic>\n                    Mip alone.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202300442","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:14:54Z","timestamp":1690269294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[4.3.1]Bicyclic FKBP Ligands Inhibit\n                    <i>Legionella Pneumophila<\/i>\n                    Infection by\n                    <i>Lp<\/i>\n                    Mip\u2010Dependent and\n                    <i>Lp<\/i>\n                    Mip\u2010Independent Mechanisms**"],"prefix":"10.1002","volume":"24","author":[{"given":"Robin C. 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