{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:33:38Z","timestamp":1772498018877,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The cell redox balance can be disrupted by the oxidation of biological peptides, eventually leading to cell death, which provides opportunities to develop cytotoxic drugs. With the aim of developing compounds capable of specifically inducing fatal redox reactions upon light irradiation, we have developed a library of copper compounds. This metal is abundant and considered essential for human health, making it particularly attractive for the development of new anticancer drugs. Copper(I) clusters with thiol ligands (including\u20055 novel ones) have been synthesized and characterized. Structures were elucidated by X\u2010ray diffraction and showed that the compounds are oligomeric clusters. The clusters display high photooxidation capacity towards cysteine \u2013 an essential amino acid \u2013 upon light irradiation in the visible range (450\u2005nm), while remaining completely inactive in the dark. This photoredox activity against a biological thiol is very encouraging for the development of anticancer photoredox drugs.The\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    assay on murine colorectal cancer cells (CT26) did not show any toxicity \u2013 whether in the dark or when exposed to 450\u2005nm light, likely because of the poor solubility of the complexes in biological medium.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202300496","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T22:44:42Z","timestamp":1695768282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Towards Copper(I) Clusters for Photo\u2010Induced Oxidation of Biological Thiols in Living Cells**"],"prefix":"10.1002","volume":"24","author":[{"given":"Lisa","family":"Gourdon\u2010Gr\u00fcnewaldt","sequence":"first","affiliation":[{"name":"Institute of Chemistry for Life and Health Sciences Laboratory for Inorganic Chemical Biology Chimie ParisTech PSL University, CNRS  11 rue Pierre et Marie Curie 75005 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Blacque","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Gasser","sequence":"additional","affiliation":[{"name":"Institute of Chemistry for Life and Health Sciences Laboratory for Inorganic Chemical Biology Chimie ParisTech PSL University, CNRS  11 rue Pierre et Marie Curie 75005 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-9632","authenticated-orcid":false,"given":"Kevin","family":"Cariou","sequence":"additional","affiliation":[{"name":"Institute of Chemistry for Life and Health Sciences Laboratory for Inorganic Chemical Biology Chimie ParisTech PSL University, CNRS  11 rue Pierre et Marie Curie 75005 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.10.013"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00236-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-021-00439-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0328-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00609F"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00573K"},{"key":"e_1_2_9_9_1","first-page":"276","author":"Rice M.","year":"1994","journal-title":"Archaeol. 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