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Stage\u2010specific gene expression in the developmental stages of parasites is tightly controlled in Plasmodium species; however, the underlying mechanisms have yet to be explored. Genome organization and gene expression for each stage of the malaria parasite need to be better characterized. Recent studies indicated that epigenetic modifications of histone proteins play a vital role in chromatin plasticity. Like other eukaryotes, Plasmodium species N\u2010terminal tail modifications form a distinct \u201chistone code,\u201d which creates the docking sites for histone reader proteins, including gene activator\/repressor complexes, to regulate gene expression. The emerging research findings shed light on various unconventional epigenetic changes in histone proteins\u2032 core\/globular domain regions, which might contribute to the chromatin organization in different developmental stages of the malaria parasite. The malaria parasite lost many transcription factors during evolution, and it is proposed that the nature of local chromatin structure essentially regulates the stage\u2010specific gene expression. This review highlights recent discoveries of unconventional histone globular domain epigenetic modifications and their functions in regulating chromatin structure dynamics in various developmental stages of malaria parasites.<\/jats:p>","DOI":"10.1002\/cbic.202300596","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T13:25:48Z","timestamp":1702301148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite"],"prefix":"10.1002","volume":"25","author":[{"given":"C. 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