{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:04:01Z","timestamp":1790816641481,"version":"4.1.0"},"reference-count":146,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017169","name":"Centre de Regulaci\u00f3 Gen\u00f2mica","doi-asserted-by":"publisher","award":["CRG\/2022\/005673"],"award-info":[{"award-number":["CRG\/2022\/005673"]}],"id":[{"id":"10.13039\/100017169","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The connection between 3d (Cu) and 4d (Mo) via the \u201cMo\u2212S\u2212Cu\u201d unit is called Mo\u2212Cu antagonism. Biology offers case studies of such interactions in metalloproteins such as Mo\/Cu\u2212CO Dehydrogenases (Mo\/Cu\u2212CODH), and Mo\/Cu Orange Protein (Mo\/Cu\u2212ORP). The CODH significantly maintains the CO level in the atmosphere below the toxic level by converting it to non\u2013toxic CO<jats:sub>2<\/jats:sub> for respiring organisms. Several models were synthesized to understand the structure\u2013function relationship of these native enzymes. However, this interaction was first observed in ruminants, and they convert molybdate (MoO<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup>) into tetrathiomolybdate (MoS<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup>; TTM), reacting with cellular Cu to yield biological unavailable Mo\/S\/Cu cluster, then developing Cu\u2010deficiency diseases. These findings inspire the use of TTM as a Cu\u2010sequester drug, especially for treating Cu\u2010dependent human diseases such as Wilson diseases (WD) and cancer. It is well known that a balanced Cu homeostasis is essential for a wide range of biological processes, but negative consequence leads to cell toxicity. Therefore, this review aims to connect the Mo\u2212Cu antagonism in metalloproteins and anti\u2010copper therapy.<\/jats:p>","DOI":"10.1002\/cbic.202300679","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:04:21Z","timestamp":1704960261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molybdenum\u2010Copper Antagonism In Metalloenzymes And Anti\u2010Copper Therapy"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-0031","authenticated-orcid":false,"given":"Biplab K.","family":"Maiti","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of sciences Cluster University of Jammu Canal Road  Jammu 180001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Moura","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE Department of Chemistry NOVA School of Science and Technology (FCT NOVA) Universidade NOVA de Lisboa  Campus de Caparica Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J. G.","family":"Moura","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE Department of Chemistry NOVA School of Science and Technology (FCT NOVA) Universidade NOVA de Lisboa  Campus de Caparica Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400443z"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00556"},{"key":"e_1_2_9_3_1","first-page":"1","volume-title":"Molybdenum and tungsten-containing enzymes-An overview. In: R. Hille, C. Schulzke, M.\u2005L. Kirk","author":"Maia L. B.","year":"2017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja000955h"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212640899"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111687"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400327t"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/141553a0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002185960004836X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(83)85047-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600062468"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b02811"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja056500f"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03343"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2004.07.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201200551"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2014.04.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b02906"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biochem2030013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213635"},{"key":"e_1_2_9_21_1","first-page":"617","volume":"2","author":"Pan Q.","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800905774574066"},{"key":"e_1_2_9_23_1","first-page":"76","volume-title":"in: Orphan Diseases and Orphan Drugs","author":"Walshe M.","year":"1986"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/b901614g"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(02)00298-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085049"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900104z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/34.4.295"},{"key":"e_1_2_9_29_1","first-page":"1666","volume":"9","author":"Redman B. G.","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jics.2021.100117"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179907"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2381"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00461"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9269-1_3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409230490496577"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00128"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2019.148118"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-130-5-1097"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(00)81505-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja205073j"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi026514n"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.8884"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.522441"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01408"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi1017182"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja406136f"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-005-0661-5"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20230"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC47705C"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CP00858B"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212640899"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-014-1188-4"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-016-1359-6"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.202200053"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00314a054"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5088(87)90570-4"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.076851"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4005814"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00651"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC04239F"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic902066m"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic050294v"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41280f"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt50759a"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900044e"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2003.12.002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.05.006"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-014-1107-8"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0108767302089717"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101792"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.7b00840"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201806228"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01350"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-8545(84)85056-0"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198109341"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/zaac.201300034"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.001005"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/185020a0"},{"key":"e_1_2_9_79_1","first-page":"61","volume-title":"Onderzoekingen over de z.g. diarrhee-weiden (scouring pastures) in den Wieringermeer polder. Versl. Landbouwk. Onderz.","author":"Brouwer E.","year":"1938"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19740053"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1979.0090"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(68)90014-5"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50212a006"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(00)80232-5"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.2.188"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91433-X"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2004.02.004"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000006200"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.7.1251"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0901-751"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(97)90241-6"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094232"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0682-x"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(93)90052-B"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00480-4"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.72"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.12.018"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-030409-143539"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00202A"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12371"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09376-7"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.01.003"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar000012p"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00041C"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1618"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5086"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.851_w.x"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360390250649"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.04.021"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18951-1"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3980"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0843"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-016-1342-2"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00103C"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.4.807"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00038.2011"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MT00149H"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.03.001"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.000176"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812808106"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.647099"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-327"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63625-6.00003-3"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102912"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2018.043.07.2819432"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19873-2"},{"key":"e_1_2_9_130_1","first-page":"869","volume":"2","author":"Weiss K. H.","year":"2017","journal-title":"Hepatology"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi801926e"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja029054u"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08102-z"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.001"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07733"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.07.004"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04695"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2447"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.012"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2233"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318431110"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.4.521"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1482274"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0315"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16938"},{"key":"e_1_2_9_146_1","first-page":"1887","volume":"9","author":"Blockhuys S.","year":"2021","journal-title":"Biomedicine"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202300679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:07:53Z","timestamp":1760285273000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202300679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":146,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3,15]]}},"alternative-id":["10.1002\/cbic.202300679"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202300679","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300679"}}