{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:30:21Z","timestamp":1780497021311,"version":"3.54.1"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["#313440\/2019-0"],"award-info":[{"award-number":["#313440\/2019-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["#429463\/2018-9"],"award-info":[{"award-number":["#429463\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pt(II) and Pd(II) coordinating N\u2010donor ligands have been extensively studied as anticancer agents after the success of cisplatin. In this work, a novel bidentate N\u2010donor ligand, the N\u2010[[4\u2010(phenylmethoxy)phenyl]methyl]\u20102\u2010pyridinemethanamine, was designed to explore the antiparasitic, antiviral and antitumor activity of its Pt(II) and Pd(II) complexes. Chemical and spectroscopic characterization confirm the formation of [M<jats:bold>L<\/jats:bold>Cl<jats:sub>2<\/jats:sub>] complexes, where M=Pt(II) and Pd(II). Single crystal X\u2010ray diffraction confirmed a square\u2010planar geometry for the Pd(II) complex. Spectroscopic characterization of the Pt(II) complex suggests a similar structure. <jats:sup>1<\/jats:sup>H NMR, <jats:sup>195<\/jats:sup>Pt NMR and HR\u2010ESI\u2010MS(+) analysis of DMSO solution of complexes indicated that both compounds exchange the chloride <jats:italic>trans<\/jats:italic> to the pyridine for a solvent molecule with different reaction rates. The ligand and the two complexes were tested for <jats:italic>in\u2005vitro<\/jats:italic> antitumoral, antileishmanial, and antiviral activity. The Pt(II) complex resulted in a GI<jats:sub>50<\/jats:sub> of 10.5\u2005\u03bcM against the NCI\/ADR\u2010RES (multidrug\u2010resistant ovarian carcinoma) cell line. The ligand and the Pd(II) complex showed good anti\u2010SARS\u2010CoV\u20102 activity with around 65\u2009% reduction in viral replication at a concentration of 50\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbic.202300696","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T07:59:07Z","timestamp":1703577547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel Bidentate Amine Ligand and the Interplay between Pd(II) and Pt(II) Coordination and Biological Activity"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-6434","authenticated-orcid":false,"given":"Laiane S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Institute of Chemistry University of Campinas  Cidade Universit\u00e1ria Zeferino Vaz \u2013 Bar\u00e3o Geraldo Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-0915","authenticated-orcid":false,"given":"Let\u00edcia B.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Institute of Biology University of Campinas Cidade Universit\u00e1ria Zeferino Vaz \u2013  Bar\u00e3o Geraldo, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele D.","family":"Affonso","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Campinas Cidade Universit\u00e1ria Zeferino Vaz \u2013  Bar\u00e3o Geraldo, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-4045","authenticated-orcid":false,"given":"Igor A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Uberl\u00e2ndia  Jo\u00e3o Naves de \u00c1vila Avenue 2121 \u2013 Santa M\u00f4nica, Uberl\u00e2ndia Minas Gerais Brazil"},{"name":"School of Molecular and Cellular Biology Faculty of Biological Sciences University of Leeds  Woodhouse Leeds LS2 9JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5045-8947","authenticated-orcid":false,"given":"Jennyfer C.","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Campinas  Cidade Universit\u00e1ria Zeferino Vaz \u2013 Bar\u00e3o Geraldo Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-3600","authenticated-orcid":false,"given":"Gustavo C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Campinas  Cidade Universit\u00e1ria Zeferino Vaz \u2013 Bar\u00e3o Geraldo Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-1003","authenticated-orcid":false,"given":"Mark","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Molecular and Cellular Biology Faculty of Biological Sciences University of Leeds  Woodhouse Leeds LS2 9JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-7923","authenticated-orcid":false,"given":"Ana Carolina G.","family":"Jardim","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Uberl\u00e2ndia  Jo\u00e3o Naves de \u00c1vila Avenue 2121 \u2013 Santa M\u00f4nica, Uberl\u00e2ndia Minas Gerais Brazil"},{"name":"Institute of Biosciences Humanities and Exact Sciences S\u00e3o Paulo State University  Crist\u00f3v\u00e3o Colombo street 2265 - Jardim Nazareth. S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-6463","authenticated-orcid":false,"given":"Douglas H.","family":"Nakahata","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Federal University of Goi\u00e1s  Esperan\u00e7a Avenue, Campus Samambaia. Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-9967","authenticated-orcid":false,"given":"Jos\u00e9 R.","family":"Sabino","sequence":"additional","affiliation":[{"name":"Institute of Physics Federal University of Goi\u00e1s  Esperan\u00e7a Avenue, Campus Samambaia. Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o E.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Campinas Cidade Universit\u00e1ria Zeferino Vaz \u2013  Bar\u00e3o Geraldo, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-6562","authenticated-orcid":false,"given":"Danilo C.","family":"Miguel","sequence":"additional","affiliation":[{"name":"Institute of Biology University of Campinas Cidade Universit\u00e1ria Zeferino Vaz \u2013  Bar\u00e3o Geraldo, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-8702","authenticated-orcid":false,"given":"Ana Lucia T. G.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Campinas Cidade Universit\u00e1ria Zeferino Vaz \u2013  Bar\u00e3o Geraldo, Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-2252","authenticated-orcid":false,"given":"Camilla","family":"Abbehausen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Campinas  Cidade Universit\u00e1ria Zeferino Vaz \u2013 Bar\u00e3o Geraldo Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed083p728"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(85)90001-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(97)00110-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980421n"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2011.10.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510020102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-009-0469-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152007779314062"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000217421.14090.e0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160311114509"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69424"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00271"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2019.110754"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2019.01.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e17006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103258"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja075889z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2021.106300"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001626"},{"key":"e_1_2_9_22_1","unstructured":"\u201cU.\u2005S. Food & Drug Administration (FDA) FDA-Approved Drugs Website \u201d can be found underhttps:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfmAcessed november 20 2023."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm970658w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100185c"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180811666140812231321"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666170707105416"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196426"},{"key":"e_1_2_9_28_1","first-page":"1","volume":"24","author":"Koz\u0142owska J.","year":"2019","journal-title":"Molecules"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114698"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2016.1259550"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)85674-1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1258384"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4797"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2018.09.032"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2007.09.012"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1DT11191D"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic061060u"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.11.013"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.02.011"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00359-X"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.24461"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00326a007"},{"key":"e_1_2_9_43_1","unstructured":"Test No. 107: Partition Coefficient (n-Octanol\/Water): Shake Flask Method OECD 1995 Guidelines for the Testing of Chemicals Section 1 OECD Publishing Paris."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b01238"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.07.007"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00180"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt31079a"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.05.064"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.12.016"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics7080095"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.11.004"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed083p728"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(85)90001-0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13033394"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113404"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101250"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2005.08.011"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-4622(90)80003-P"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13033394"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12103.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)83515-X"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","unstructured":"A.\u2005M.\u2005M. Santi S.\u2005M.\u2005F. Murta Mem Inst Oswaldo Cruz2022 117 e210401.","DOI":"10.1590\/0074-02760210401"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195795"},{"key":"e_1_2_9_64_1","unstructured":"Bruker SAINT APEXII 2012 Bruker AXS Inc. Madison Wisconsin USA."},{"key":"e_1_2_9_65_1","unstructured":"Bruker SADABS APEXII 2001 Bruker AXS Inc. Madison Wisconsin USA ."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.81"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.478401"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CP01851E"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct100199k"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9904009"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ02009E"},{"key":"e_1_2_9_73_1","first-page":"3166","volume":"2","author":"Garbett N. C.","year":"2007","journal-title":"Nature Protocols 2007 2\u2009:\u200912"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.11.757"},{"key":"e_1_2_9_75_1","doi-asserted-by":"crossref","unstructured":"B. Mendes K. Minori S.\u2005R. Consonni N.\u2005W. Andrews D.\u2005C. Miguel Front Cell Infect Microbiol2022 12.","DOI":"10.3389\/fcimb.2022.824494"},{"key":"e_1_2_9_76_1","first-page":"469","volume":"2018","author":"Kumar P.","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001091"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012465330-6\/50003-8"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116044"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19160-7"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202300696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:07:33Z","timestamp":1760285253000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202300696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":80,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3,15]]}},"alternative-id":["10.1002\/cbic.202300696"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202300696","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300696"}}