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Besides the oxygen regulation throughout the body, Hb plays a vital role in balancing immunological health and the redox cycle. Photoinduced ultra\u2010fast electron transfer phenomena actively participate in regulation of various kind of homeostasis involved in such biomacromolecules. In the present study we have shown that a well\u2010known mutagen Ethidium Bromide (EtBr) reduces GHb in femtosecond time scale (efficiently) upon photoexcitation after efficient recognition in the biomolecule. We have performed similar experiment by colocalizing EtBr and Iron (Fe(III)) on the micellar surface as Hb mimic in order to study the excited state EtBr dynamics to rationalize the time scale obtained from EtBr in GHb and Hb. While other experimental techniques including Dynamic Light Scattering (DLS), Zeta potential, absorbance and emission spectroscopy have been employed for the confirmation of structural perturbation of GHb compared to Hb, a detailed computational studies involving molecular docking and density functional theory (DFT) have been employed for the explanation of the experimental observations.<\/jats:p>","DOI":"10.1002\/cbic.202300721","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:01:52Z","timestamp":1705402912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Mutagen Acts as a Potent Reducing Agent of Glycated Hemoglobin: a Combined Ultrafast Electron Transfer and Computational Studies"],"prefix":"10.1002","volume":"25","author":[{"given":"Lopamudra","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Applied Optics and Photonics University of Calcutta  JD-2, Sector-III, Salt Lake Kolkata West Bengal 700 106 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivedita","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block-JD, Sector-III Salt Lake Kolkata 700106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ria","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block-JD, Sector-III Salt Lake Kolkata 700106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Nur","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block-JD, Sector-III Salt Lake Kolkata 700106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susmita","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences  Block-JD, Sector-III Salt Lake Kolkata 700106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Physics Jadavpur University  188, Raja S.C. Mallick Rd Kolkata 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monojit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Zoology Vidyasagar University Rangamati  Midnapore 721102 India"},{"name":"Department of Zoology Uluberia College University of Calcutta  Uluberia Howrah 711315 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyshi","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics University of Kalyani Nadia  Kalyani West Bengal 741245"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kallol","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Applied Optics and Photonics University of Calcutta  JD-2, Sector-III, Salt Lake Kolkata West Bengal 700 106 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Basic Science and Humanities Techno International New Town Block, DG 1\/1, Action Area 1 New Town, Rajarhat  Kolkata 700156 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-5828","authenticated-orcid":false,"given":"Samir Kumar","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. 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