{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:33:57Z","timestamp":1775086437799,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["182023"],"award-info":[{"award-number":["182023"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many actinobacterial species contain structural genes for iron\u2010dependent enzymes that consume ergothioneine by way of O<jats:sub>2<\/jats:sub>\u2010dependent dioxygenation. The resulting product ergothioneine sulfinic acid is stable under physiological conditions unless cleavage to sulfur dioxide and trimethyl histidine is catalyzed by a dedicated desulfinase. This report documents that two types of ergothioneine sulfinic desulfinases have evolved by convergent evolution. One type is related to metal\u2010dependent decarboxylases while the other belongs to the superfamily of rhodanese\u2010like enzymes. Pairs of ergothioneine dioxygenases (ETDO) and ergothioneine sulfinic acid desulfinase (ETSD) occur in thousands of sequenced actinobacteria, suggesting that oxidative ergothioneine degradation is a common activity in this phylum.<\/jats:p>","DOI":"10.1002\/cbic.202400131","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T09:10:15Z","timestamp":1712740215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Rhodanese\u2010Like Enzyme that Catalyzes Desulfination of Ergothioneine Sulfinic Acid"],"prefix":"10.1002","volume":"25","author":[{"given":"Egor Y.","family":"Nalivaiko","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Basel  Mattenstrasse 24a Basel 4002 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-1369","authenticated-orcid":false,"given":"Florian P.","family":"Seebeck","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Basel  Mattenstrasse 24a Basel 4002 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja101721e"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705932"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00365"},{"key":"e_1_2_7_5_1","unstructured":"\u00a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408624102"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14269"},{"key":"e_1_2_7_8_1","unstructured":"\u00a0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-060822-122236"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000464"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.10.372"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.01.023"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0043"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14264"},{"key":"e_1_2_7_15_1","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4442-0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201901866"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvz098"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbaa066"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00968"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c00169"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.3c00745"},{"key":"e_1_2_7_23_1","unstructured":"\u00a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.10.008"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35277-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318445"},{"key":"e_1_2_7_27_1","unstructured":"\u00a0"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.11.017"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbab006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100492"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.635672"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b01085"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh340"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syq010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn180"},{"key":"e_1_2_7_36_1","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12596"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202208746"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37182-X"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05811.x"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9846-x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqad029"},{"key":"e_1_2_7_43_1","unstructured":"\u00a0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602974200"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC00496F"},{"key":"e_1_2_7_46_1","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02105-12"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004715006616"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.36.22417"},{"key":"e_1_2_7_50_1","unstructured":"\u00a0"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.9.4407-4415.2002"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b08251"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c04091"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000244"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.107"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.05.044"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202400131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:46:20Z","timestamp":1760294780000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202400131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,5,2]]}},"alternative-id":["10.1002\/cbic.202400131"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202400131","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400131"}}