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The pathogenesis of Huntington's disease, a CAG trinucleotide repeat disorder, is similarly linked to the presence of protein fibrils formed from mutant huntingtin (mHTT) protein. Development of mHTT fibril\u2013specific radioligands has been limited by the lack of structural knowledge around mHTT and a dearth of available hit compounds for medicinal chemistry refinement. Over the past decade, the CHDI Foundation, a non\u2010for\u2010profit scientific management organisation has orchestrated a large\u2010scale screen of small molecules to identify high affinity ligands of mHTT, with lead compounds now reaching clinical maturity. Here we describe the mHTT radioligands developed to date and opportunities for further improvement of this radiotracer class.<\/jats:p>","DOI":"10.1002\/cbic.202400152","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T09:29:56Z","timestamp":1714642196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non\u2010For\u2010Profit Scientific Management"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-5354","authenticated-orcid":false,"given":"Catherine G. 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