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Opioids and non\u2010steroidal anti\u2010inflammatory drugs (NSAIDS) have been used for this purpose, but opioids cause addiction and withdrawal symptoms whereas NSAIDS have several systemic toxicities. Derivatives of the naturally occurring iboga alkaloids have previously shown promising behavior in anti\u2010addiction of morphine by virtue of their interaction with opioid receptors. On this frontier, four benzofuran analogs of the iboga family have been synthesized and their analgesic effects have been studied in formalin induced acute pain model in male Swiss albino mice at 30\u2005mg\/kg of body weight dose administered intraperitoneally. The antioxidant, anti\u2010inflammatory and neuro\u2010modulatory effects of the analogs were analyzed. Reversal of tail flick latency, restricted locomotion and anxiogenic behavior were observed in iboga alcohol, primary amide and secondary amide. Local neuroinflammatory mediators\u2019 substance P, calcitonin gene related peptide, cyclooxygenase\u20102 and p65 were significantly decreased whereas the depletion of brain derived neurotrophic factor and glia derived neurotrophic factor was overturned on iboga analog treatment. Behavioral patterns after oral administration of the best analog were also analyzed. Taken together, these results show that the iboga family of alkaloid has huge potential in pain management.<\/jats:p>","DOI":"10.1002\/cbic.202400162","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:03:36Z","timestamp":1718359416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Benzofuran Iboga\u2010Analogs Modulate Nociception and Inflammation in an Acute Mouse Pain Model"],"prefix":"10.1002","volume":"25","author":[{"given":"Tuhin","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Physiology University of Calcutta  92 APC Road West Bengal Kolkata 70009 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Applied and Interdisciplinary Sciences Indian Association for the Cultivation of Science  2A Raja S.C. 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