{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:05:16Z","timestamp":1789603516637,"version":"build-2803163510"},"reference-count":214,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human protein Abelson kinase (Abl), a tyrosine kinase, plays a pivotal role in developing chronic myeloid leukemia (CML). Abl's involvement in various signaling pathways underscores its significance in regulating fundamental biological processes, including DNA damage responses, actin polymerization, and chromatin structural changes. The discovery of the Bcr\u2010Abl oncoprotein, resulting from a chromosomal translocation in CML patients, revolutionized the understanding and treatment of the disease. The introduction of targeted therapies, starting with interferon\u2010alpha and culminating in the development of tyrosine kinase inhibitors (TKIs) like imatinib, significantly improved patient outcomes. However, challenges such as drug resistance and side effects persist, indicating the necessity of research into novel therapeutic strategies. This review describes advancements in Abl kinase inhibitor development, emphasizing rational compound design from structural and regulatory information. Strategies, including bivalent inhibitors, PROTACs, and compounds targeting regulatory domains, promise to overcome resistance and minimize side effects. Additionally, leveraging the intricate structure and interactions of Bcr\u2010Abl may provide insights into developing inhibitors for other kinases. Overall, this review highlights the importance of continued research into Abl kinase inhibition and its broader implications for therapeutic interventions targeting kinase\u2010driven diseases. It provides valuable insights and strategies that may guide the development of next\u2010generation therapies.<\/jats:p>","DOI":"10.1002\/cbic.202400296","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T16:09:40Z","timestamp":1721059780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Structure\u2010Guided Drug Design Targeting Abl Kinase: How Structure and Regulation Can Assist in Designing New Drugs"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-5643","authenticated-orcid":false,"given":"Diego M.","family":"Martins.","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Instituto de Ci\u00eancias Exatas Universidade Federal de Minas Gerais  31270-901 Pampulha, MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-2958","authenticated-orcid":false,"given":"Philipe O.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  31270-901 Pampulha, MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7723-0675","authenticated-orcid":false,"given":"Lucas A.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Instituto de Ci\u00eancias Exatas Universidade Federal de Minas Gerais  31270-901 Pampulha, MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-5907","authenticated-orcid":false,"given":"Vin\u00edcius G.","family":"Maltarollo","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  31270-901 Pampulha, MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-4084","authenticated-orcid":false,"given":"Adolfo H.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Instituto de Ci\u00eancias Exatas Universidade Federal de Minas Gerais  31270-901 Pampulha, MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1280"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155161"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202571"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1166"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118232"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00622"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.09.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9588-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01454-13"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/283826a0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3139re6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.04.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077225"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902328"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.07.001"},{"key":"e_1_2_9_17_1","volume-title":"StatPearls","author":"Patel R.","year":"2024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5486.1938"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.01.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4187"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.09.028"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029828"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21702"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00252-y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010117"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3563"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171191"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950170408"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi800446b"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1862342"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56499-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01952"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-1180"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2011.07.004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.01.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.438382"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.12.002"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040144"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.13.7557015"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971438n"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b00600"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160327"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvq015"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205017"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607656103"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001680"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2754"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807988105"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.02.029"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901443h"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01361"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.035"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1932"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00194-6"},{"key":"e_1_2_9_55_1","volume":"4","author":"Liu B. A.","year":"2011","journal-title":"Sci. Signaling"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6470"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415944"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00060-1"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.06.006"},{"key":"e_1_2_9_60_1","volume":"4","author":"Marasco M.","year":"2020","journal-title":"J. Struct. Biol."},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141492"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-183665"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.046"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005401200"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.5.2883"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-280"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12430"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500060k"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00191-0"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00623-2"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00741-9"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00202"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.21"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.12.017"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1938"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01348-2"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.04.006"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0617"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1168"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3139"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2018.1435183"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44376-8"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106552"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2760-4"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CB00153E"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00127"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00847"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0111-6"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220931926"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.197756"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.019"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411325200"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3410"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00720B"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00154F"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.038"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1082"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184210"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0624-2"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13801"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114442"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106156"},{"key":"e_1_2_9_103_1","first-page":"4236","volume":"62","author":"Nagar B.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci200153c"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2012.12.009"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30890"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167349"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444906047287"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912462126"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801337200"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.5194\/mr-3-91-2022"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1404"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.22.6646"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb780"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.18.5572"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0896-696"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8853"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00905.x"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301581y"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009617666171002142659"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01040"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.264"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022538"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-169828"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03126-6"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00048-4"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33933"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014689"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.08.004"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2539-0"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.07.006"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1793"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41894-3"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs35449k"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115542"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.128354"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-017-0005-9"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105637"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.707901"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000796"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.01.015"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.12.7587"},{"key":"e_1_2_9_143_1","first-page":"117","volume":"9","author":"Zhao X.","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi051493t"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0811"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.264903"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400323c"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500701u"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1841-1"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1354-3"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.53"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.194"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4504"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3343"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.9.1399"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1276"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02313-6"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.196"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12544"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.11.014"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00543"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112981"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114290"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507634"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36956-5"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.9b01158"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.09.041"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00348"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01264"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02058"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00967"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.009"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00247"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1236"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104994"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051710-093308"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-00686-2"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109237"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28352"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104850"},{"key":"e_1_2_9_181_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/d41573-019-00043-6","volume":"18","author":"Mullard A.","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113318"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja983515n"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17963"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402526"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47404-0"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-024-01108-3"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02076"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-017-0125-1"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00320"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1459"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2012.20.1.019"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.10.21"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707875"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00475"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.12.006"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13248"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11595"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00154"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202105383"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202203878"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-044805"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113786"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00561"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b02960"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806037"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-019-0249-6"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2416"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202404195"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00272"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1317880"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.3c00149"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2018.1555587"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013691118"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202400296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:27:15Z","timestamp":1760275635000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202400296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":214,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,12,2]]}},"alternative-id":["10.1002\/cbic.202400296"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202400296","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"2024-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400296"}}