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Remarkably, differential scanning calorimetry (DSC) and simultaneous synchrotron small\u2010angle\/wide\u2010angle X\u2010ray scattering (SAXS\/WAXS) show that crystallization of PEG is suppressed by \u03b1CD, provided that the cyclodextrin content is sufficient. A hexagonal mesophase is formed instead. The \u03b1CD threading reduces the conformational flexibility of PEG, and hence suppresses crystallization. These results show that addition of cyclodextrins can be used to tune the crystallization of peptide\u2010polymer conjugates and potentially other polymer\/biomolecular hybrids.<\/jats:p>","DOI":"10.1002\/cbic.202400396","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:59:21Z","timestamp":1716361161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cyclodextrin\u2010Induced Suppression of PEG Crystallization from the Melt in a PEG\u2010Peptide Conjugate"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-0926","authenticated-orcid":false,"given":"Ian W.","family":"Hamley","sequence":"first","affiliation":[{"name":"School of Chemistry Food Biosciences and Pharmacy University of Reading  Whiteknights Reading RG6 6AD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-0162","authenticated-orcid":false,"given":"Valeria","family":"Castelletto","sequence":"additional","affiliation":[{"name":"School of Chemistry Food Biosciences and Pharmacy University of Reading  Whiteknights Reading RG6 6AD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hermida\u2010Merino","sequence":"additional","affiliation":[{"name":"DUBBLE-CRG @ ESRF CS40220 The European Synchrotron  71, Avenue des Martyrs 38043 Grenoble Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"DUBBLE-CRG @ ESRF CS40220 The European Synchrotron  71, Avenue des Martyrs 38043 Grenoble Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205962"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/369133a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0001766"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/a900939f"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1455"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr970027"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/js950534b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr970025p"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1576"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-9592(03)00258-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.05.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.10.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/b920608f"},{"key":"e_1_2_8_14_1","volume":"132","author":"Tsai C. 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