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The detection of replicating parasites within human red blood cells is of paramount importance, requiring appropriate diagnostic tools. Herein, we design and apply a silicon rhodamine\u2010fused glibenclamide (\n                    <jats:bold>SiR\u2010glib<\/jats:bold>\n                    ). We first test this far\u2010red fluorescent, fluorogenic and endoplasmic reticulum\u2010targeting sulfonylurea in mammalian cells and pancreatic islets, before characterizing its labeling performance in red blood cells infected with the asexual developmental stages of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . We further combine\n                    <jats:bold>SiR\u2010glib<\/jats:bold>\n                    with a portable smartphone\u2010based microscope to easily and rapidly identify parasitized red blood cells, providing proof of principle for diagnostic use in rural endemic areas without major healthcare facilities.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202400628","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:19:43Z","timestamp":1740539983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Silicon Rhodamine\u2010fused Glibenclamide to Label and Detect Malaria\u2010infected Red Blood Cells"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0475-4615","authenticated-orcid":false,"given":"Claudia","family":"Bastl","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases Parasitology Heidelberg University 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