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This includes cyclic voltammetry and the analysis of four new structures by single crystal X\u2010ray diffraction. The compounds cytotoxic potential has been determined by MTT screening against pancreatic carcinoma (MIA PaCa\u20102), ovarian adenocarcinoma (A2780), breast adenocarcinomas (MDA\u2010MB\u2010231 and MCF\u20107) and normal epithelial retinal (ARPE\u201019). The compounds show a general trend, where increasing the number of aromatic rings in the molecule yields an increase in cytotoxicity and follows the trend anthracenyl&gt;naphthyl&gt;phenyl&gt;methyl. The compounds are particularly sensitive to the triple negative cancer cell line MDA\u2010MB\u2010231, and the potential modes of action have been studied by production of reactive oxygen species using fluorescence microscopy and cell morphology using Scanning Electron Microscopy. All assays highlight the ferrocenyl \u03b2\u2010diketonate with an anthracenyl substituent to be the lead compound in this library. The decomposition of this compound was also observed within cells, yielding a cytotoxic fluorescent molecule, which has been visualized by confocal microscopy.<\/jats:p>","DOI":"10.1002\/cbic.202400759","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:29:14Z","timestamp":1729769354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferrocenyl \u03b2\u2010Diketonate Compounds: Extended Ring Systems for Improved Anticancer Activity"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-3472","authenticated-orcid":false,"given":"Benjamin J.","family":"Hofmann","sequence":"first","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"},{"name":"Department of Chemistry University of Warwick  Coventry CV4\u20097SH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas T.","family":"Aljohani","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cicovacki","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-7450","authenticated-orcid":false,"given":"Derek T.","family":"Warren","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-1240","authenticated-orcid":false,"given":"Anastasia","family":"Sobolewski","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-131X","authenticated-orcid":false,"given":"Tameryn","family":"Stringer","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"},{"name":"School of Chemistry University of Waikato  Hamilton 3240 New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-129X","authenticated-orcid":false,"given":"Rianne M.","family":"Lord","sequence":"additional","affiliation":[{"name":"School of Chemistry Pharmacy and Pharmacology University of East Anglia  Norwich, Norfolk NR4\u20097TJ UK"},{"name":"Department of Chemistry University of Warwick  Coventry CV4\u20097SH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"164","volume":"19","author":"Abbaspour N.","year":"2014","journal-title":"J. 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