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Elevated levels of H\n                    <jats:sub>2<\/jats:sub>\n                    S can result in acute or chronic poisoning, whereas lower concentrations are involved in regulating diverse physiological and pathological activities within the human body. Moreover, it actively participates in maintaining normal cellular function by exerting cell protection and anti\u2010apoptotic effects. In recent years, extensive research has been conducted to explore the physiological significance of H\n                    <jats:sub>2<\/jats:sub>\n                    S and its potential applications in developing prodrugs. To further unravel the biological and clinical potential of H\n                    <jats:sub>2<\/jats:sub>\n                    S, H\n                    <jats:sub>2<\/jats:sub>\n                    S donors have gained widespread utilization. These compounds facilitate our understanding of the specific functional aspects governed by H\n                    <jats:sub>2<\/jats:sub>\n                    S and hold promise as potential therapeutic agents. Therefore, it is necessary to study H\n                    <jats:sub>2<\/jats:sub>\n                    S as a delivery vehicle at the cellular and\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    levels. This review provides an overview of advancements made over the past five years regarding H\n                    <jats:sub>2<\/jats:sub>\n                    S donors and their applications in biology, encompassing indirectly released donors of carbonyl sulfide (COS), directly released small molecule donors, Nanocomposite scaffolds, and hydrogels.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202400817","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T08:53:53Z","timestamp":1733820833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Research Progress in the Field of Hydrogen Sulfide Donors in the Last Five Years"],"prefix":"10.1002","volume":"26","author":[{"given":"Qian","family":"Pang","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science Shanxi University  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