{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:40:22Z","timestamp":1791668422196,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by the deposition of amyloid\u2010\u03b2 (A\u03b2) peptides, which aggregate into toxic structures such as oligomers, fibrils, and plaques. The presence of these A\u03b2 aggregates in the brain plays a crucial role in the pathophysiology, leading to synaptic dysfunction and cognitive impairment. Understanding how physiological factors affect A\u03b2 aggregation is essential, and therefore, exploring their influence\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    will likely provide insights into their role in AD pathology. In this study, we investigated the effects of physiological, free amino acids on A\u03b2 aggregation dynamics. We focused on positively charged amino acids, particularly lysine, and employed a chemical modification, methylation, to neutralize its charge. Our analyses revealed that modified lysine significantly reduced A\u03b2 aggregation, indicating that charge distribution of amino acids plays a crucial role in modulating A\u03b2 aggregation behavior. These findings enhance our understanding of the regulatory factors influencing A\u03b2 aggregation and highlight important considerations for future research on A\u03b2.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202400906","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T22:39:59Z","timestamp":1737499199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Charge Modification of Lysine Mitigates Amyloid\u2010\u03b2 Aggregation"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2434-4893","authenticated-orcid":false,"given":"HaeMin","family":"Kwon","sequence":"first","affiliation":[{"name":"Integrated Science and Engineering Division Underwood International College Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiMin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"InWook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MinSeol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Jung-gu Seoul 04620 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-7082","authenticated-orcid":false,"given":"YoungSoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Department of Integrative Biotechnology &amp; Translational Medicine Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Amyloid Solution Inc.  Seongnam-si Gyeonggi 13486 Republic of Korea"},{"name":"Department of Psychiatry Institute of Behavioral Science in Medicine Yonsei University College of Medicine  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye","family":"Yun Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"},{"name":"Yonsei Institute of Pharmaceutical Science College of Pharmacy Yonsei University  85\u2005Songdogwahak-ro, Yeonsu-gu Incheon 21983 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00069a001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90312-E"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.160696"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00449"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408153101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608207200"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi027378p"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.097766"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605629103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.097766"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2012.700287"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202400906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202400906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202400906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:20:34Z","timestamp":1777706434000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202400906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,3]]}},"alternative-id":["10.1002\/cbic.202400906"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202400906","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400906"}}