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Exploring the underlying mechanisms on a molecular level can open new avenues in understanding the host\u2010pathogen interactions. Any imbalance of the heme concentration has a direct impact on the bacterial growth and survival. Thus, heme\u2010regulated proteins that are involved in heme homeostasis poise to be promising targets for research. Similarly, naturally occurring compounds, including cysteine\u2010rich peptides from either plant secondary metabolites or venom toxins from vertebrates and invertebrates, have been studied for their therapeutic potential. NCR247 is such a cysteine\u2010rich peptide, known to be crucial for nitrogenase activity in\n                    <jats:italic>M. truncatula<\/jats:italic>\n                    and its symbiotic relation with\n                    <jats:italic>S. meliloti<\/jats:italic>\n                    . NCR247\u2010derived peptides were suggested to serve as high\u2010affinity heme\u2010binding molecules with remarkable heme\u2010capturing properties. A comprehensive biochemical and computational analysis of NCR247\u2010derived peptides, however, redefines their heme\u2010binding capacity and consequently their potential therapeutic role.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202400920","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T07:34:35Z","timestamp":1735544075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Insights into the Heme\u2010Binding Potential of Plant NCR247\u2010Derived Peptides"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8277-113X","authenticated-orcid":false,"given":"Sonali M.","family":"Vaidya","sequence":"first","affiliation":[{"name":"Department: Pharmaceutical Biochemistry and Bioanalytics Institution: Pharmaceutical Institute University of Bonn, Address 1: An der Immenburg 4  Bonn 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