{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:42Z","timestamp":1790187042274,"version":"4.1.0"},"reference-count":82,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22434005"],"award-info":[{"award-number":["22434005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21991132"],"award-info":[{"award-number":["21991132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21971053"],"award-info":[{"award-number":["21971053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK2060000081"],"award-info":[{"award-number":["WK2060000081"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2025,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spherical nucleic acids (SNAs) consist of DNA strands arranged radially and packed densely on the surface of nanoparticles. Due to their unique properties, which are not found in naturally occurring linear or circular DNA, SNAs have gained widespread attention in fields such as sensing, nanomedicine, and colloidal assembly. The rapidly evolving applications of SNAs have driven a modernization of their syntheses to meet different needs. Recently, several advanced approaches have emerged, enabling ultrafast, quantitative, and low\u2010cost SNA synthesis with maximal DNA grafting through \u201ccounterintuitive\u201d processes like freezing and dehydration. This concept paper discusses these critical developments from a synthetic perspective, focusing on their underlying mechanisms and broad implications, with a goal of inspiring future research in related fields.<\/jats:p>","DOI":"10.1002\/cbic.202400976","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T11:38:11Z","timestamp":1734953891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advanced Synthesis of Spherical Nucleic Acids: A Limit\u2010Pursuing Game with Broad Implications"],"prefix":"10.1002","volume":"26","author":[{"given":"Meiyun","family":"Ye","sequence":"first","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Center for Bioanalytical Chemistry School of Chemistry and Materials Science University of Science and Technology of China  Hefei, Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Hefei University of Technology  Hefei, Anhui 230009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-5147","authenticated-orcid":false,"given":"Zhaoxiang","family":"Deng","sequence":"additional","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Center for Bioanalytical Chemistry School of Chemistry and Materials Science University of Science and Technology of China  Hefei, Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/382607a0"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja209351u"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260901"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl802958f"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja021096v"},{"key":"e_1_2_6_6_1","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja052255o"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC00066E"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805532"},{"key":"e_1_2_6_10_1","unstructured":"\u00a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125559"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl072471q"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac3004055"},{"key":"e_1_2_6_14_1","unstructured":"\u00a0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410744"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/prechem.3c00056"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902805116"},{"key":"e_1_2_6_18_1","unstructured":"\u00a0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00225"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06560"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06508"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c12078"},{"key":"e_1_2_6_23_1","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3647"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.209"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c00656"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC01171A"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC03049E"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.6023\/A24040147"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00299"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw2399"},{"key":"e_1_2_6_32_1","unstructured":"\u00a0"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja304118z"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702998"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414752"},{"key":"e_1_2_6_36_1","unstructured":"\u00a0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712921"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08990"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006318"},{"key":"e_1_2_6_40_1","unstructured":"\u00a0"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.7.1558"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl071108g"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0613582"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac901459v"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja303787e"},{"key":"e_1_2_6_46_1","unstructured":"\u00a0"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006839"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505951112"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3014055"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0549-3"},{"key":"e_1_2_6_51_1","unstructured":"\u00a0"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04885"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202400113"},{"key":"e_1_2_6_54_1","unstructured":"\u00a0"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00217"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202312975"},{"key":"e_1_2_6_57_1","unstructured":"\u00a0"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c00568"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.05.011"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh8508"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202202458"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28627-8"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410353"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317463"},{"key":"e_1_2_6_65_1","unstructured":"\u00a0"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915907117"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12750"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5329.1078"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03833"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102330"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax7983"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410247"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp9525806"},{"key":"e_1_2_6_74_1","unstructured":"\u00a0"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3703.1589"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/212194a0"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101456"},{"key":"e_1_2_6_78_1","unstructured":"\u00a0"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(62)90002-9"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1076"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814352"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b03253"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202400976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:00:30Z","timestamp":1760292030000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202400976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,16]]}},"alternative-id":["10.1002\/cbic.202400976"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202400976","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"2024-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400976"}}