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Derivatives of perylene, a pentacyclic aromatic hydrocarbon, demonstrate pronounced antiviral activity. These compounds act primarily as membrane\u2010active singlet oxygen photogenerators, disrupting virions and inhibiting their fusion with the host cell membrane. Modification of the perylene core allows for chemical diversification of antiviral photosensitizers. Additionally, achieving a bathochromic shift of the absorption band is crucial for effective treatment of superficial lesions, as it facilitates deeper tissue penetration of therapeutic light. In this work, donor\u2010acceptor perylenylethylenes and (perylenethienyl)ethylenes were synthesized and evaluated for their spectral properties, singlet oxygen photogeneration, and inhibitory activity against vesicular stomatitis virus (VSV), a representative enveloped virus. Incorporation of a thiophene moiety into the molecule significantly enhanced both the singlet oxygen generation ability and the antiviral activity. These findings provide useful insights into the relationship between the structure, spectral\/photochemical properties, and biological activity of perylene\u2010based photosensitizers.<\/jats:p>","DOI":"10.1002\/cbic.202401019","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:39:08Z","timestamp":1741693148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Donor\u2010Acceptor (Perylenethienyl)Ethylenes as Singlet Oxygen\u2010Photogenerating Viral Inhibitors**"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-3321","authenticated-orcid":false,"given":"Maxim S.","family":"Krasilnikov","sequence":"first","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Miklukho-Maklaya 16\/10  117997 Moscow Russia"},{"name":"Department of Chemistry Lomonosov Moscow State University Leninskie Gory 1\u20133  119991 Moscow 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