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Accordingly, there is a critical need to precisely address the gap in the biochemical and physiological mechanisms that underlie neurodegenerative diseases to promote advancements in therapeutic interventions. Parkinson's Disease (PD), the second most common neurodegenerative disorder after Alzheimer's, demands further research focused on unravelling the rather intricate molecular mechanisms that drive its progression upon different cell signaling cues. While alpha\u2010synuclein aggregation and mitochondrial dysfunction are two cellular hallmarks of the molecular pathophysiology of PD, few drugs are currently in clinical trials for treatment of PD, which warrants further studies to identify new therapeutic molecular targets. Herein, we briefly highlight some of the reported roles of ferroptosis, a\u00a0modality of cell death that is driven by iron\u2010dependent phospholipid peroxidation, and its regulation by glutathione peroxidase 4 (GPX4). We discuss the interconnectedness between lipid peroxidation and GPX4 regulation in the context of molecular pathogenesis of PD. \u00a0Future studies are imperative in investigating the physiological role of ferroptosis and the translational impact of ferroptosis\u2010specific modulators in studying PD biology.<\/jats:p>","DOI":"10.1002\/cbic.202401052","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:42:46Z","timestamp":1747035766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fine\u2010Tuning Ferroptosis by Modulating GPX4 and Its Potential in Mitigating Neuronal Degeneration in Parkinson\u2032s Disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Michael M.","family":"Shahid","sequence":"first","affiliation":[{"name":"Department of Chemistry Illinois State University  Normal IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Hohman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Illinois State University  Normal IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9513-2939","authenticated-orcid":false,"given":"Mohamed","family":"Eldeeb","sequence":"additional","affiliation":[{"name":"Department of Chemistry Illinois State University  Normal IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.02.005"},{"key":"e_1_2_9_2_1","volume":"9","author":"Blesa J.","year":"2015","journal-title":"Front. 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