{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:08:55Z","timestamp":1789664935240,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["471424360"],"award-info":[{"award-number":["471424360"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["945846"],"award-info":[{"award-number":["945846"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The question of lanthanide (Ln) uptake in Ln\u2010using bacteria has gained a lot of attention in recent years, and the existence of specific Ln\u2010binding metallophores, termed lanthanophores, has been postulated. Here, the recently isolated metallophore methylolanthanin (MLL), which is shown to be involved in Ln metabolism of\n                    <jats:italic>Methylobacterium extorquens<\/jats:italic>\n                    AM1 along the structurally related siderophore rhodopetrobactin B (RPB B), is investigated. The total synthesis of both chelators as well as Ln\u2010binding investigations employing a multitude of spectroscopic methods is reported. Compared to MLL, RPB B has a higher binding affinity for Fe\n                    <jats:sup>3+<\/jats:sup>\n                    . Unexpectedly, both metallophores seem to precipitate Lns under biologically relevant conditions (pH and concentration range). Therefore, a solubility product of \u221212.07 \u00b1 0.24 mol\n                    <jats:sup>2<\/jats:sup>\n                    \u2009L\n                    <jats:sup>\u22122<\/jats:sup>\n                    for the precipitated Eu\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010MLL complex is reported. Furthermore, a combination of single\u2010cell inductively coupled plasma mass spectrometry and Liquid Chromatography\u2010Mass Spectrometry (LC\u2010MS) analysis of bacterial supernatant to investigate the Nd accumulation as well as MLL secretion under Fe limitation in\n                    <jats:italic>M. extorquens<\/jats:italic>\n                    AM1 is used. Finally, ion mobility spectrometry\u2010mass spectrometry and quantum chemical calculations are used to investigate the RPB B and MLL complexation in the gas phase with Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and all rare earth elements (except Pm). The results challenge the classical siderophore\u2010like Ln uptake (via simple solubilization) through MLL and underline again a potential complex interplay between Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and Ln\n                    <jats:sup>3+<\/jats:sup>\n                    in microbial Ln uptake.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500312","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:51:52Z","timestamp":1764658312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-3328","authenticated-orcid":false,"given":"Sophie M.","family":"Gutenthaler\u2010Tietze","sequence":"first","affiliation":[{"name":"Department of Chemistry Ludwig Maximilians University of Munich  Butenandtstra\u00dfe 5\u201313 81377 Munich Germany"},{"name":"Chair of Bioinorganic Chemistry Heinrich Heine University D\u00fcsseldorf  Universit\u00e4tsstr. 1 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5460-1309","authenticated-orcid":false,"given":"Michael","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ludwig Maximilians University of Munich  Butenandtstra\u00dfe 5\u201313 81377 Munich Germany"},{"name":"Chair of Bioinorganic Chemistry Heinrich Heine University D\u00fcsseldorf  Universit\u00e4tsstr. 1 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manh Tri","family":"Phi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ludwig Maximilians University of Munich  Butenandtstra\u00dfe 5\u201313 81377 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6759","authenticated-orcid":false,"given":"Patrick","family":"Weis","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry Karlsruhe Institute of Technology  Fritz\u2010Haber\u2010Weg 2 76131 Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1245-0466","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Drobot","sequence":"additional","affiliation":[{"name":"Institute of Resource Ecology Biogeochemie Helmholtz\u2010Zentrum Dresden\u2010Rossendorf e.V.  Bautzner Landstra\u00dfe 400 01328 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6845-3439","authenticated-orcid":false,"given":"Alexander","family":"K\u00f6hrer","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry University of M\u00fcnster  Corrensstra\u00dfe 48 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-9587","authenticated-orcid":false,"given":"Robin","family":"Steudtner","sequence":"additional","affiliation":[{"name":"Institute of Resource Ecology Biogeochemie Helmholtz\u2010Zentrum Dresden\u2010Rossendorf e.V.  Bautzner Landstra\u00dfe 400 01328 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-6787","authenticated-orcid":false,"given":"Uwe","family":"Karst","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry University of M\u00fcnster  Corrensstra\u00dfe 48 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-7204","authenticated-orcid":false,"given":"N. Cecilia","family":"Martinez\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology University of California\u2013Berkeley  California 94720 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-136X","authenticated-orcid":false,"given":"Lena J.","family":"Daumann","sequence":"additional","affiliation":[{"name":"Chair of Bioinorganic Chemistry Heinrich Heine University D\u00fcsseldorf  Universit\u00e4tsstr. 1 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-26809-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7628"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4156-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050480"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2011.01.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12249"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00642"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904090"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09842"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102940"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05945-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01830-19"},{"key":"e_1_2_8_14_1","first-page":"S00652911220001","volume-title":"Advances in Microbial Physiology","author":"Daumann L. J.","year":"2022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5766-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14208"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07352689509701922"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10498-014-9246-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01614a021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/177526a0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/b906679a"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.921635"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-01841-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2013.06.006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.01.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00254"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar800211j"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322096121"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14078"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0284-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo049803l"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202303669"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201800130"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT01238E"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202300811"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900184"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1AN01449H"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124881"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c06775"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02494"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90612-9"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi981194m"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-024-00249-z"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-9140(88)80082-1"},{"key":"e_1_2_8_46_1","first-page":"607","volume":"42","author":"Gladilovich D. B.","year":"1988","journal-title":"Chem. Pap. \u2010 Chem. Zvesti"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114741"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3AN00741C"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/3527602852"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0567739476001551"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP03326B"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202500312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:59:16Z","timestamp":1783108756000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202500312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbic.202500312"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202500312","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2024-9f26t","asserted-by":"object"}]},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500312"}}