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Their antimicrobial activity is evaluated against both methicillin\u2010sensitive (MSSA) and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA), and selected compounds are also assessed for cytotoxicity, yielding promising therapeutic indices. Notably, the complexation of antifungal azoles to the rhenium core enhances antimicrobial efficacy, with a compound exhibiting up to a 32\u2010fold improvement in minimum inhibitory concentration (MIC) values relative to the parent azole. Structure\u2013activity relationships indicate that cationic <jats:italic>fac<\/jats:italic>\u2010[Re(CO)<jats:sub>3<\/jats:sub>]<jats:sup>+<\/jats:sup> complexes consistently outperform their <jats:italic>cis<\/jats:italic>\u2010[Re(CO)<jats:sub>2<\/jats:sub>]<jats:sup>+<\/jats:sup> counterparts, and mechanistic studies suggest that active complexes disrupt bacterial membrane integrity and interfere with the electron transport chain. Complementary small\u2010angle X\u2010ray scattering and <jats:italic>in silico<\/jats:italic> analysis corroborate these findings, offering insights into the mechanism of action of this family of complexes.<\/jats:p>","DOI":"10.1002\/cbic.202500368","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T07:14:26Z","timestamp":1750835666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Boosting Antibiotic Efficacy of Azole Drugs against Methicillin\u2010Resistant <i>Staphylococcus Aureus<\/i> by Coordination to Rhenium Carbonyl Complexes"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-2283","authenticated-orcid":false,"given":"Kevin","family":"Schindler","sequence":"first","affiliation":[{"name":"Department of Chemistry Fribourg University  Chemin Du Mus\u00e9e 9 1700 Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-7981","authenticated-orcid":false,"given":"Gozde","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fribourg University  Chemin Du Mus\u00e9e 9 1700 Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fribourg University  Chemin Du Mus\u00e9e 9 1700 Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Nasiri","family":"Sovari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fribourg University  Chemin Du Mus\u00e9e 9 1700 Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9414-2098","authenticated-orcid":false,"given":"Youri","family":"Cortat","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fribourg University  Chemin Du Mus\u00e9e 9 1700 Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas F. 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