{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:27:35Z","timestamp":1783110455308,"version":"3.54.6"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018948","name":"Saudi Arabian Cultural Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Metal\u2013organic frameworks (MOFs) have emerged as highly tunable materials for targeted and controlled drug delivery. In this study, NUIG4 is presented as a multifunctional MOF\u2010based carrier capable of encapsulating both anticancer and antimicrobial therapeutics. NUIG4 exhibits high\u2010surface area, water stability, and suitable porosity, supporting the efficient loading of a range of drug molecules. Its dual anticancer drug delivery performance is assessed using doxorubicin (DOX) and 5\u2010fluorouracil (5\u2010FU). Co\u2010loading studies demonstrate successful encapsulation of both drugs and synergistic cytotoxicity in MDA\u2010MB\u2010231 breast cancer cells, indicating that the MOF preserves and potentially enhances the therapeutic efficacy of both drugs. Furthermore, NUIG4 is assessed as a carrier for antibiotics, including tetracycline (TET), isoniazid (INH), and pyrazinamide (PYZ), demonstrating sustained, pH\u2010responsive release. TET@NUIG4 retain potent antimicrobial activity against\n                    <jats:italic>S. aureus and E. coli<\/jats:italic>\n                    , with minimum inhibition concentration values matching those of the free drug, while INH and PYZ highlight NUIG4's potential for tuberculosis\u2010directed delivery. Spectroscopic analyses and kinetic modeling support a chemisorption\u2010based mechanism and efficient, sustained release. These findings establish NUIG4 as one of the few MOFs reported, capable of both dual anticancer drug codelivery and antibiotic encapsulation and release, suitable for targeting both cancer and infectious diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500484","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:44:26Z","timestamp":1767941066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding the Therapeutic Potential of NUIG4: A Multifunctional Metal\u2013Organic Framework for Dual Anticancer and Antibacterial Drug Delivery"],"prefix":"10.1002","volume":"27","author":[{"given":"Manal","family":"Alrashidi","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"},{"name":"Department of Chemistry College of Science University of Hafr AlBatin  P. O. Box 1803 Hafr Al Batin 31991 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"McHugh","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Jordan","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"McHugh","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine Lambe Institute for Translational Research University of Galway  H91 TK33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos G.","family":"Efthymiou","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayle","family":"Leonard","sequence":"additional","affiliation":[{"name":"School of Natural Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Farras","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3is\u00edn","family":"Dwyer","sequence":"additional","affiliation":[{"name":"School of Medicine Lambe Institute for Translational Research University of Galway  H91 TK33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Boyd","sequence":"additional","affiliation":[{"name":"School of Natural Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-7747","authenticated-orcid":false,"given":"Constantina","family":"Papatriantafyllopoulou","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Sciences College of Science and Engineering University of Galway  H91 TK 33 Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02176A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196585"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05310"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704303"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar000034b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS90059F"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2022.108300"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2017.07.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NA00061J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b00733"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c02552"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315075"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200256v"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c01089"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02025A"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.202300244"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102443"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA04441J"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NA01075A"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB02562D"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c10272"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.08.015"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-75668-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00642"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00687"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c01630"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR06019J"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158522"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125295"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst12050578"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03886"},{"key":"e_1_2_8_35_1","first-page":"101017","author":"Wang Y.","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MA00735A"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102217"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2020.100254"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c06175"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12030232"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-024-04152-z"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.2c01632"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2024.126597"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14131081"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b08451"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02753J"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2022.126933"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC03635A"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC04218E"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306178"},{"key":"e_1_2_8_51_1","first-page":"765","volume":"15","author":"Jin W.","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09562-x"},{"key":"e_1_2_8_53_1","first-page":"1517289","author":"Hassanein M. M.","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00460G"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CE01215G"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00460G"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CE01215G"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214121"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09617"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21698"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-017-0745-z"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25092119"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217166"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CE00885E"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.9b01302"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MA00450B"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c03751"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.4c02250"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.3c00169"},{"key":"e_1_2_8_70_1","first-page":"1","volume-title":"Zur Theorie der Sogenannten Absorption Gel\u00f6ster Stoffe","author":"Lagergren S.","year":"1898"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-9592(98)00112-5"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma10020205"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.013"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-998-0130-x"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175949"},{"key":"e_1_2_8_79_1","first-page":"102","volume":"38","author":"Langmuir I.","year":"1915","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_8_80_1","first-page":"3039817","author":"Ayawei N.","year":"2017","journal-title":"J. Chem."},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179292"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23041991"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(67)90105-5"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202500484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:00:21Z","timestamp":1783108821000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202500484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbic.202500484"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202500484","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500484"}}